Melissa A Day1, L Charles Ward1, Dawn M Ehde2, Beverly E Thorn3, John Burns4, Amanda Barnier5,6, Jason B Mattingley1,7, Mark P Jensen2. 1. School of Psychology, University of Queensland, Brisbane, Queensland, Australia. 2. Department of Rehabilitation Medicine, University of Washington, Seattle, Washington, USA. 3. Department of Psychology, University of Alabama, Tuscaloosa, Alabama, USA. 4. Department of Behavioral Sciences, Rush University Medical Center, Chicago, Illinois, USA. 5. Department of Cognitive Science, Macquarie University, Sydney, New South Wales, Australia. 6. Australian Research Council Centre of Excellence in Cognition and its Disorders, Macquarie University, Sydney, New South Wales, Australia. 7. Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.
Abstract
OBJECTIVE: This pilot trial compared the feasibility, tolerability, acceptability, and effects of group-delivered mindfulness meditation (MM), cognitive therapy (CT), and mindfulness-based cognitive therapy (MBCT) for chronic low back pain (CLBP). SETTING: University of Queensland Psychology Clinic. SUBJECTS:Participants were N = 69 (intent-to-treat [ITT] sample) adults with CLBP. DESIGN: A pilot, assessor-blinded randomized controlled trial. METHODS: Participants were randomized to treatments. The primary outcome was pain interference; secondary outcomes were pain intensity, physical function, depression, and opioid medication use. The primary study end point was post-treatment; maintenance of gains was evaluated at three- and six-month follow-up. RESULTS:Ratings of acceptability, and ratios of dropout and attendance showed that MBCT was acceptable, feasible, and well tolerated, with similar results found across conditions. For the ITT sample, large improvements in post-treatment scores for pain interference, pain intensity, physical function, and depression were found (P < 0.001), with no significant between-group differences. Analysis of the follow-up data (N = 43), however, revealed that MBCT participants improved significantly more than MM participants on pain interference, physical function, and depression. The CT group improved more than MM in physical function. The MBCT and CT groups did not differ significantly on any measures. CONCLUSIONS: This is the first study to examine MBCT for CLBP management. The findings show that MBCT is a feasible, tolerable, acceptable, and potentially efficacious treatment option for CLBP. Further, MBCT, and possibly CT, could have sustained benefits that exceed MM on some important CLBP outcomes. A future definitive randomized controlled trial is needed to evaluate these treatments and their differences.
RCT Entities:
OBJECTIVE: This pilot trial compared the feasibility, tolerability, acceptability, and effects of group-delivered mindfulness meditation (MM), cognitive therapy (CT), and mindfulness-based cognitive therapy (MBCT) for chronic low back pain (CLBP). SETTING: University of Queensland Psychology Clinic. SUBJECTS:Participants were N = 69 (intent-to-treat [ITT] sample) adults with CLBP. DESIGN: A pilot, assessor-blinded randomized controlled trial. METHODS:Participants were randomized to treatments. The primary outcome was pain interference; secondary outcomes were pain intensity, physical function, depression, and opioid medication use. The primary study end point was post-treatment; maintenance of gains was evaluated at three- and six-month follow-up. RESULTS: Ratings of acceptability, and ratios of dropout and attendance showed that MBCT was acceptable, feasible, and well tolerated, with similar results found across conditions. For the ITT sample, large improvements in post-treatment scores for pain interference, pain intensity, physical function, and depression were found (P < 0.001), with no significant between-group differences. Analysis of the follow-up data (N = 43), however, revealed that MBCT participants improved significantly more than MM participants on pain interference, physical function, and depression. The CT group improved more than MM in physical function. The MBCT and CT groups did not differ significantly on any measures. CONCLUSIONS: This is the first study to examine MBCT for CLBP management. The findings show that MBCT is a feasible, tolerable, acceptable, and potentially efficacious treatment option for CLBP. Further, MBCT, and possibly CT, could have sustained benefits that exceed MM on some important CLBP outcomes. A future definitive randomized controlled trial is needed to evaluate these treatments and their differences.
Authors: Elizabeth K Seng; Alexandra B Singer; Christopher Metts; Amy S Grinberg; Zarine S Patel; Maya Marzouk; Lauren Rosenberg; Melissa Day; Mia T Minen; Richard B Lipton; Dawn C Buse Journal: Headache Date: 2019-09-26 Impact factor: 5.887
Authors: Elizabeth K Seng; Alexandra B Conway; Amy S Grinberg; Zarine S Patel; Maya Marzouk; Lauren Rosenberg; Christopher Metts; Melissa A Day; Mia T Minen; Dawn C Buse; Richard B Lipton Journal: Neurol Clin Pract Date: 2021-06
Authors: Carrie E Brintz; Martin D Cheatle; Laura M Dember; Alicia A Heapy; Manisha Jhamb; Amanda J Shallcross; Jennifer L Steel; Paul L Kimmel; Daniel Cukor Journal: Semin Nephrol Date: 2021-01 Impact factor: 4.472
Authors: M A Day; D M Ehde; J Burns; L C Ward; J L Friedly; B E Thorn; M A Ciol; E Mendoza; J F Chan; S Battalio; J Borckardt; M P Jensen Journal: Contemp Clin Trials Date: 2020-04-14 Impact factor: 2.226
Authors: Estela María Pardos-Gascón; Lucas Narambuena; César Leal-Costa; Antonio Jesús Ramos-Morcillo; María Ruzafa-Martínez; Carlos J van-der Hofstadt Román Journal: Int J Environ Res Public Health Date: 2021-06-29 Impact factor: 3.390