Tingting Feng1, Malmo Vegard2,3, Linn B Strand1, Lars E Laugsand2,3, Bjørn Mørkedal4, Dagfinn Aune5,6,7, Lars Vatten1, Hanne Ellekjaer8,9, Jan P Loennechen2,3, Kenneth Mukamal10, Imre Janszky1,11,12. 1. Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway. 2. Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway. 3. Clinic of Cardiology, St. Olav's Hospital, Trondheim, Norway. 4. Department of Cardiology, Vestfold Hospital Trust, Tønsberg, Norway. 5. Department of Epidemiology and Biostatistics, Imperial College London, London, UK. 6. Department of Nutrition, Bjørknes University College, Oslo, Norway. 7. Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway. 8. Stroke Unit, Department of Internal Medicine, St Olav's Hospital, Trondheim, Norway. 9. Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway. 10. Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA. 11. Regional Center for Health Care Improvement, St Olav's Hospital, Trondheim University Hospital, Norway. 12. Department of Neurology, Medical School, University of Pécs, Pécs, Hungary.
Abstract
OBJECTIVE: Atrial fibrillation (AF) is the most common arrhythmia and has been described as a global epidemic. Although AF is associated with both obesity and its metabolic consequences, little is known about the association between metabolically healthy obesity and AF. METHODS: In a population-based study, 47,870 adults were followed for incident AF from 2006 to 2008 until 2015. Participants were classified according to BMI and metabolic status (using waist circumference, triglycerides, high-density lipoprotein cholesterol, blood pressure, and glucose) at baseline. RESULTS: During a median follow-up of 8.1 years, 1,758 participants developed AF. Compared with metabolically healthy individuals with BMI < 25 kg/m2 , the multivariable-adjusted hazard ratios for metabolically healthy and unhealthy obesity were 1.6 (95% CI: 1.2 to 2.1) and 1.6 (95% CI: 1.3 to 1.9), respectively. AF risk increased according to the severity of obesity. CONCLUSIONS: Metabolically healthy and unhealthy obesity increased AF risk to a similar extent. Severity of obesity was positively associated with AF risk regardless of metabolic status.
OBJECTIVE:Atrial fibrillation (AF) is the most common arrhythmia and has been described as a global epidemic. Although AF is associated with both obesity and its metabolic consequences, little is known about the association between metabolically healthy obesity and AF. METHODS: In a population-based study, 47,870 adults were followed for incident AF from 2006 to 2008 until 2015. Participants were classified according to BMI and metabolic status (using waist circumference, triglycerides, high-density lipoprotein cholesterol, blood pressure, and glucose) at baseline. RESULTS: During a median follow-up of 8.1 years, 1,758 participants developed AF. Compared with metabolically healthy individuals with BMI < 25 kg/m2 , the multivariable-adjusted hazard ratios for metabolically healthy and unhealthy obesity were 1.6 (95% CI: 1.2 to 2.1) and 1.6 (95% CI: 1.3 to 1.9), respectively. AF risk increased according to the severity of obesity. CONCLUSIONS: Metabolically healthy and unhealthy obesity increased AF risk to a similar extent. Severity of obesity was positively associated with AF risk regardless of metabolic status.
Authors: Maoxiang Zhao; Wenjuan Du; Qianqian Zhao; Yating Chen; Bin Li; Zhonghui Xie; Zihao Fu; Nan Zhang; Xiaowei Cheng; Xiaoqian Li; Siyu Yao; Miao Wang; Chi Wang; Shouling Wu; Hao Xue; Yang Li Journal: Front Cardiovasc Med Date: 2022-06-28
Authors: Zakaria Almuwaqqat; Wesley T O'Neal; Faye L Norby; Pamela L Lutsey; Elizabeth Selvin; Elsayed Z Soliman; Lin Y Chen; Alvaro Alonso Journal: J Am Heart Assoc Date: 2019-09-28 Impact factor: 5.501
Authors: Nele Gessler; Stephan Willems; Daniel Steven; Jens Aberle; Ruken Oezge Akbulak; Nils Gosau; Boris A Hoffmann; Christian Meyer; Arian Sultan; Roland Tilz; Julia Vogler; Peter Wohlmuth; Susanne Scholz; Melanie A Gunawardene; Christian Eickholt; Jakob Lüker Journal: Europace Date: 2021-10-09 Impact factor: 5.214