Magdalena Jędrychowska1, Rafał Januszek2,3, Krzysztof Plens4, Andrzej Surdacki5, Stanisław Bartuś5, Dariusz Dudek6,7. 1. 2nd Department of Cardiology and Cardiovascular Interventions, University Hospital, Kopernika 17 street, 31-501 Kraków, Poland. 2. 2nd Department of Cardiology and Cardiovascular Interventions, University Hospital, Kopernika 17 street, 31-501 Kraków, Poland. jaanraf@interia.pl. 3. University of Physical Education Department of Clinical Rehabilitation, Al. Jana Pawla II 78, 31-501 Kraków, Poland. jaanraf@interia.pl. 4. KCRI, Cracow, Poland. 5. 2nd Department of Cardiology, Jagiellonian University Medical College, Krakow, Poland. 6. 2nd Department of Cardiology, Jagiellonian University Medical College. 7. Department of Interventional Cardiology, Jagiellonian University Medical College, Krakow, Poland.
Abstract
BACKGROUND: Myocardial infarction with non-obstructive coronary arteries (MINOCA) occurs more often in women. AIM: We sought to assess the relationship between sex and clinical outcomes during follow-up in patients after MINOCA and to identify predictors of major adverse cardiac and cerebrovascular events (MACCE). METHODS: The study comprised 134 patients (78 women) at the mean age of 61.6 years, who were diagnosed with MINOCA at the Department of Cardiology between January 2015 and June 2018. The mean follow-up duration was 609.5 ± 412.2 days. Pri-mary study endpoints were MACCE, which included all-cause death, myocardial infarction, reintervention, and cerebral stroke. Secondary endpoints were recurrent chest pain during follow-up and rehospitalisation for reasons other than MACCE. RESULTS: Kaplan-Meier survival curve analysis did not reveal any significant differences in the frequency of MACCE (p = 0.63) or mortality rate (p = 0.29) between men and women. There was no significant impact of sex on secondary study endpoints either. Sex was not identified as a predictor of primary or secondary study endpoints in univariate or multivariate analysis. Troponin index (risk ratio [RR] 1.002; 95% confidence interval [CI] 1.0005-1.0026, p = 0.004), age (RR 1.04; 95% CI 1.008-1.065, p = 0.01), serum creatinine level (RR 1.01; 95% CI 1.001-1.01, p = 0.02), hyperlipidaemia (RR 0.26; 95% CI 0.07-0.75, p = 0.01), and prior venous thromboembolic disease (RR 8.28; 95% CI 1.15-38, p = 0.04) were found to be predictors of MACCE in multivariate analysis. CONCLUSIONS: Sex was not found to be significantly associated with clinical outcomes during the follow-up period in patients with MINOCA.
BACKGROUND:Myocardial infarction with non-obstructive coronary arteries (MINOCA) occurs more often in women. AIM: We sought to assess the relationship between sex and clinical outcomes during follow-up in patients after MINOCA and to identify predictors of major adverse cardiac and cerebrovascular events (MACCE). METHODS: The study comprised 134 patients (78 women) at the mean age of 61.6 years, who were diagnosed with MINOCA at the Department of Cardiology between January 2015 and June 2018. The mean follow-up duration was 609.5 ± 412.2 days. Pri-mary study endpoints were MACCE, which included all-cause death, myocardial infarction, reintervention, and cerebral stroke. Secondary endpoints were recurrent chest pain during follow-up and rehospitalisation for reasons other than MACCE. RESULTS: Kaplan-Meier survival curve analysis did not reveal any significant differences in the frequency of MACCE (p = 0.63) or mortality rate (p = 0.29) between men and women. There was no significant impact of sex on secondary study endpoints either. Sex was not identified as a predictor of primary or secondary study endpoints in univariate or multivariate analysis. Troponin index (risk ratio [RR] 1.002; 95% confidence interval [CI] 1.0005-1.0026, p = 0.004), age (RR 1.04; 95% CI 1.008-1.065, p = 0.01), serum creatinine level (RR 1.01; 95% CI 1.001-1.01, p = 0.02), hyperlipidaemia (RR 0.26; 95% CI 0.07-0.75, p = 0.01), and prior venous thromboembolic disease (RR 8.28; 95% CI 1.15-38, p = 0.04) were found to be predictors of MACCE in multivariate analysis. CONCLUSIONS: Sex was not found to be significantly associated with clinical outcomes during the follow-up period in patients with MINOCA.
Entities:
Keywords:
clinical outcomes; follow-up; myocardial infarction with non-obstructive coronary arteries; predictors; sex
Authors: Zbigniew Siudak; Leszek Bryniarski; Krzysztof Piotr Malinowski; Wojciech Wańha; Wojciech Wojakowski; Sławomir Surowiec; Robert Balan; Sławomir Januszek; Artur Pawlik; Natalia Siwiec; Krzysztof Bryniarski; Andrzej Surdacki; Jacek Legutko; Krzysztof Bartuś; Stanisław Bartuś; Rafał Januszek Journal: J Clin Med Date: 2022-03-04 Impact factor: 4.241