Literature DB >> 30604798

Photoactive chelates for radiolabelling proteins.

Larissa S Eichenberger1, Malay Patra, Jason P Holland.   

Abstract

Photochemical reactions are an attractive foundation for the synthesis of radiolabelled antibodies, immunoglobulin fragments and other proteins/peptides. The synthesis, 68Ga-radiochemistry and photochemical reactivity of three macrocyclic chelates functionalised with an arylazide group is described. Experiments with trastuzumab confirmed that photoradiochemistry facilitates fast, one-pot synthesis of radiolabelled proteins.

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Year:  2019        PMID： 30604798     DOI： 10.1039/c8cc09660k

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  7 in total

1.  Light-Induced Radiosynthesis of 89Zr-DFO-Azepin-Onartuzumab for Imaging the Hepatocyte Growth Factor Receptor.

Authors:  Simon Klingler; Rachael Fay; Jason P Holland
Journal:  J Nucl Med       Date:  2020-01-10       Impact factor: 10.057

2.  Simultaneous Photoradiochemical Labeling of Antibodies for Immuno-Positron Emission Tomography.

Authors:  Malay Patra; Simon Klingler; Larissa S Eichenberger; Jason P Holland
Journal:  iScience       Date:  2019-03-07

Review 3.  Current outlook on radionuclide delivery systems: from design consideration to translation into clinics.

Authors:  Oleksii O Peltek; Albert R Muslimov; Mikhail V Zyuzin; Alexander S Timin
Journal:  J Nanobiotechnology       Date:  2019-08-21       Impact factor: 10.435

4.  Microfluidic Preparation of 89Zr-Radiolabelled Proteins by Flow Photochemistry.

Authors:  Daniel F Earley; Amaury Guillou; Dion van der Born; Alex J Poot; Jason P Holland
Journal:  Molecules       Date:  2021-02-02       Impact factor: 4.411

5.  Photoactivatable bis(thiosemicarbazone) derivatives for copper-64 radiotracer synthesis.

Authors:  Daniel F Earley; Jose Esteban Flores; Amaury Guillou; Jason P Holland
Journal:  Dalton Trans       Date:  2022-03-29       Impact factor: 4.390

6.  Charting the Chemical and Mechanistic Scope of Light-Triggered Protein Ligation.

Authors:  Daniel F Earley; Amaury Guillou; Simon Klingler; Rachael Fay; Melanie Gut; Faustine d'Orchymont; Shamisa Behmaneshfar; Linus Reichert; Jason P Holland
Journal:  JACS Au       Date:  2022-02-08

Review 7.  Recent Advances in Bioorthogonal Click Chemistry for Efficient Synthesis of Radiotracers and Radiopharmaceuticals.

Authors:  Sajid Mushtaq; Seong-Jae Yun; Jongho Jeon
Journal:  Molecules       Date:  2019-10-02       Impact factor: 4.411
  7 in total

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