Lucia Libanez Bessa Campelo Braga1, Alberto Novaes Ramos2, Manuel Bonfim Braga Neto3, Anderson Fuentes Ferreira2, Dulciene Maria Magalhães Queiroz4, Danielle Calheiros Campelo Maia3, Carlos Henrique Alencar2, Jorg Heukelbach2,5. 1. Clinical Research Unit/Biomedicine Institute, Department of Internal Medicine, School of Medicine, Federal University, Rua Coronel Nunes de Melo 1315, Rodolfo Teófilo, Fortaleza, Ceara, 60430270, Brazil. lucialib@terra.com.br. 2. Department of Community Health, School of Medicine, Federal University of Ceará, Fortaleza, Brazil. 3. Clinical Research Unit/Biomedicine Institute, Department of Internal Medicine, School of Medicine, Federal University, Rua Coronel Nunes de Melo 1315, Rodolfo Teófilo, Fortaleza, Ceara, 60430270, Brazil. 4. Laboratory of Research in Bacteriology, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil. 5. Division of Tropical Health and Medicine, College of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, Australia.
Abstract
BACKGROUND: Gastric cancer (GC) is an important cause of morbidity and mortality worldwide. However, population-based data on GC mortality dynamics in low and middle income countries are scarce. METHODS: We analyzed GC mortality in Brazil based on all GC-related deaths registered 2000-2015. RESULTS: A total of 17,374,134 deaths were recorded, with GC identified in 214,808 (1.24%) cases-203,941 (94.9%) as underlying cause, and 10,867 (5.1%) as associated cause of death. Adjusted rates for age and sex was 6.85 deaths/100,000 inhabitants [95% confidence interval (CI) 6.73-6.97]. The highest mortality rates were found in males [10.00; rate ratio (RR) 1.85; 95% CI 1.78-1.91; p < 0.0001] and patients ≥ 45 years of age (24.98; RR 3.79; 95% CI 3.55-4.05; p < 0.0001). The South (7.56; RR 1.62; 95% CI 1.50-1.76; p < 0.0001) and Southeast (7.36; RR 1.59; 95% CI 1.48-1.71; p < 0.0001) regions had the highest regional rates. Spatial and spatiotemporal high-risk mortality areas in 2004-2007 were located mainly in the South, Southeast, and Central-West regions. After 2008, the Northeast region became a high-risk area, especially Ceará State. CONCLUSION: GC remains a significant public health problem with high mortality burden and unequal distribution in Brazilian states. The new patterns in poorer regions and the high risk in some specific populations show a clear process of epidemiological transition over time. There is a need to strengthen nationwide epidemiological monitoring, surveillance, prevention, and control for GC in the country.
BACKGROUND:Gastric cancer (GC) is an important cause of morbidity and mortality worldwide. However, population-based data on GC mortality dynamics in low and middle income countries are scarce. METHODS: We analyzed GC mortality in Brazil based on all GC-related deaths registered 2000-2015. RESULTS: A total of 17,374,134 deaths were recorded, with GC identified in 214,808 (1.24%) cases-203,941 (94.9%) as underlying cause, and 10,867 (5.1%) as associated cause of death. Adjusted rates for age and sex was 6.85 deaths/100,000 inhabitants [95% confidence interval (CI) 6.73-6.97]. The highest mortality rates were found in males [10.00; rate ratio (RR) 1.85; 95% CI 1.78-1.91; p < 0.0001] and patients ≥ 45 years of age (24.98; RR 3.79; 95% CI 3.55-4.05; p < 0.0001). The South (7.56; RR 1.62; 95% CI 1.50-1.76; p < 0.0001) and Southeast (7.36; RR 1.59; 95% CI 1.48-1.71; p < 0.0001) regions had the highest regional rates. Spatial and spatiotemporal high-risk mortality areas in 2004-2007 were located mainly in the South, Southeast, and Central-West regions. After 2008, the Northeast region became a high-risk area, especially Ceará State. CONCLUSION: GC remains a significant public health problem with high mortality burden and unequal distribution in Brazilian states. The new patterns in poorer regions and the high risk in some specific populations show a clear process of epidemiological transition over time. There is a need to strengthen nationwide epidemiological monitoring, surveillance, prevention, and control for GC in the country.
Authors: Lucia Libanez Bessa Campelo Braga; Anderson Fuentes Ferreira; Fernando Antônio Siqueira Pinheiro; Tiago Gomes da Silva Benigno; Jorg Heukelbach; Daniel Barros de Castro; Dulciene Maria Magalhães Queiroz; Fábio Miyajima; Alberto Novaes Ramos Journal: Rev Panam Salud Publica Date: 2022-08-18
Authors: Manuel B Braga-Neto; Deiziane V S Costa; Dulciene M M Queiroz; Felipe S Maciel; Michelle S de Oliveira; Antônio B Viana-Junior; Flávia A Santos; Renata F C Leitao; Gerly A C Brito; Paulo R L Vasconcelos; Lucia L B C Braga Journal: Oxid Med Cell Longev Date: 2021-11-27 Impact factor: 6.543