| Literature DB >> 30603391 |
Young-Dong Kim1, Prasad Pofali2, Tae-Eun Park3, Bijay Singh3, Kihyun Cho3, Sushila Maharjan3, Prajakta Dandekar4, Ratnesh Jain2, Yun-Jaie Choi3, Rohidas Arote1, Chong-Su Cho3.
Abstract
Gene therapy holds a great promise and has been extensively investigated to improve bone formation and regeneration therapies in bone tissue engineering. A variety of osteogenic genes can be delivered by combining different vectors (viral or non-viral), scaffolds and delivery methodologies. Ex vivo & in vivo gene enhanced tissue engineering approaches have led to successful osteogenic differentiation and bone formation. In this article, we review recent advances of gene therapy-based bone tissue engineering discussing strengths and weaknesses of various strategies as well as general overview of gene therapy.Keywords: Bone morphogenetic protein; Bone tissue engineering; Gene therapy; Non-viral vector; Viral vector
Year: 2016 PMID： 30603391 PMCID： PMC6170855 DOI： 10.1007/s13770-016-9063-8
Source DB: PubMed Journal: Tissue Eng Regen Med ISSN： 1738-2696 Impact factor: 4.169