Masayuki Tojikubo1, Yuji Tajiri2. 1. 1Tenjinkai Shin-Koga Hospital, Tenjin-machi 120, Kurume, 830-8577 Japan. 2. 2Division of Endocrinology and Metabolism, Kurume University School of Medicine, Asahi-machi 67, Kurume, 830-0011 Japan.
Abstract
AIMS: To compare and evaluate effects of two DPP-4 inhibitors with different excretion routes on systemic and renal hemodynamics in Japanese patients with type 2 diabetes mellitus. METHODS: Seventy-three outpatients with type 2 diabetes who had been treated by 50 mg/day of sitagliptin (S) for at least 1 year were enrolled and prescribed 5 mg/day of linagliptin (L) instead of S for the next 1 year. RESULTS: After the initiation of S, the systolic and diastolic blood pressure decreased significantly. However, after switching to L for 1 year they increased significantly and returned to a comparable level as those before S treatment. The increase in serum creatinine or uric acid levels and the decrease in eGFR after S initiation were completely stopped or reversed after switching to L. The change in eGFR after the initiation of S was negatively correlated with the eGFR value at 1 year before switching. CONCLUSIONS: The administration of S had an obvious effect on the systemic or renal hemodynamics in contrast to the fact that the administration of L had no effect on these parameters. It is thus important to use these agents with different excretion routes, properly taking the patients' renal function into account.
AIMS: To compare and evaluate effects of two DPP-4 inhibitors with different excretion routes on systemic and renal hemodynamics in Japanese patients with type 2 diabetes mellitus. METHODS: Seventy-three outpatients with type 2 diabetes who had been treated by 50 mg/day of sitagliptin (S) for at least 1 year were enrolled and prescribed 5 mg/day of linagliptin (L) instead of S for the next 1 year. RESULTS: After the initiation of S, the systolic and diastolic blood pressure decreased significantly. However, after switching to L for 1 year they increased significantly and returned to a comparable level as those before S treatment. The increase in serum creatinine or uric acid levels and the decrease in eGFR after S initiation were completely stopped or reversed after switching to L. The change in eGFR after the initiation of S was negatively correlated with the eGFR value at 1 year before switching. CONCLUSIONS: The administration of S had an obvious effect on the systemic or renal hemodynamics in contrast to the fact that the administration of L had no effect on these parameters. It is thus important to use these agents with different excretion routes, properly taking the patients' renal function into account.
Entities:
Keywords:
Blood pressure; Linagliptin; Sitagliptin; Type 2 diabetes; eGFR
Authors: M Takihata; A Nakamura; K Tajima; T Inazumi; Y Komatsu; H Tamura; S Yamazaki; Y Kondo; M Yamada; M Kimura; Y Terauchi Journal: Diabetes Obes Metab Date: 2013-01-24 Impact factor: 6.577
Authors: Anthony H Barnett; Holger Huisman; Russell Jones; Maximilian von Eynatten; Sanjay Patel; Hans-Juergen Woerle Journal: Lancet Date: 2013-08-13 Impact factor: 79.321