Yukako Tatsumi1,2,3, Akiko Morimoto3, Fumie Soyano4, Tetsuo Shimoda4, Naomi Miyamatsu3, Yuko Ohno2, Shiro Sakaguchi4. 1. 1Department of Preventive Medicine and Epidemiology Informatics, National Cerebral and Cardiovascular Center, 5-7-1 Fujishirodai, Suita, Osaka 565-8565 Japan. 2. 2Department of Mathematical Health Science, Graduate School of Medicine, Osaka University, Suita, Osaka Japan. 3. 3Department of Clinical Nursing, Shiga University of Medical Science, Otsu, Shiga Japan. 4. 4Saku Central Hospital, Saku, Nagano Japan.
Abstract
OBJECTIVE: To investigate the risk of decreased estimated glomerular filtration rate (eGFR) and proteinuria among individuals with borderline diabetes. METHODS: This 5-year cohort study involved 2849 participants aged 30-79 years without diabetes or chronic kidney disease at baseline (April 2008-March 2009). Participants were categorized into two groups-normoglycemia and borderline diabetes-based on the results of a 75-g oral glucose tolerance test at baseline. Participants underwent annual comprehensive medical check-ups during the follow-up period until March 2014. Main outcomes were defined as proteinuria ≥[1+] or eGFR <60 ml/min/1.73 m2. Cox proportional hazards regression was used to estimate the hazard ratio (HR) and 95 % confidence interval (CI) of eGFR <60 ml/min/1.73 m2 and proteinuria ≥[1+] for the borderline diabetes group compared with the normoglycemia group. RESULTS: During the follow-up period, 335 individuals developed eGFR <60 ml/min/1.73 m2 and 136 individuals developed proteinuria ≥[1+]. Participants in the borderline diabetes group did not have a significantly higher risk of eGFR <60 ml/min/1.73 m2 or proteinuria ≥[1+] after multivariable adjustment. However, participants with borderline diabetes who were also diagnosed with borderline diabetes at the endpoint examination had a significantly higher risk of proteinuria ≥[1+] compared with participants with normoglycemia who also had normoglycemia at the endpoint examination; the HR (95 % CI) was 1.76 (1.11-2.78). CONCLUSIONS: Persistent borderline diabetes significantly increases the risk of proteinuria.
OBJECTIVE: To investigate the risk of decreased estimated glomerular filtration rate (eGFR) and proteinuria among individuals with borderline diabetes. METHODS: This 5-year cohort study involved 2849 participants aged 30-79 years without diabetes or chronic kidney disease at baseline (April 2008-March 2009). Participants were categorized into two groups-normoglycemia and borderline diabetes-based on the results of a 75-g oral glucose tolerance test at baseline. Participants underwent annual comprehensive medical check-ups during the follow-up period until March 2014. Main outcomes were defined as proteinuria ≥[1+] or eGFR <60 ml/min/1.73 m2. Cox proportional hazards regression was used to estimate the hazard ratio (HR) and 95 % confidence interval (CI) of eGFR <60 ml/min/1.73 m2 and proteinuria ≥[1+] for the borderline diabetes group compared with the normoglycemia group. RESULTS: During the follow-up period, 335 individuals developed eGFR <60 ml/min/1.73 m2 and 136 individuals developed proteinuria ≥[1+]. Participants in the borderline diabetes group did not have a significantly higher risk of eGFR <60 ml/min/1.73 m2 or proteinuria ≥[1+] after multivariable adjustment. However, participants with borderline diabetes who were also diagnosed with borderline diabetes at the endpoint examination had a significantly higher risk of proteinuria ≥[1+] compared with participants with normoglycemia who also had normoglycemia at the endpoint examination; the HR (95 % CI) was 1.76 (1.11-2.78). CONCLUSIONS: Persistent borderline diabetes significantly increases the risk of proteinuria.
Authors: K Yamagata; K Ishida; T Sairenchi; H Takahashi; S Ohba; T Shiigai; M Narita; A Koyama Journal: Kidney Int Date: 2006-11-22 Impact factor: 10.612
Authors: K Hiragushi; H Sugimoto; K Shikata; T Yamashita; N Miyatake; Y Shikata; J Wada; I Kumagai; M Fukushima; H Makino Journal: Diabetes Res Clin Pract Date: 2001-09 Impact factor: 5.602
Authors: William C Knowler; Elizabeth Barrett-Connor; Sarah E Fowler; Richard F Hamman; John M Lachin; Elizabeth A Walker; David M Nathan Journal: N Engl J Med Date: 2002-02-07 Impact factor: 91.245