Literature DB >> 30602521

High Prevalence of Bedaquiline Resistance in Treatment-Naive Tuberculosis Patients and Verapamil Effectiveness.

Hasan Ghajavand1,2, Mansour Kargarpour Kamakoli1,2, Sharareh Khanipour1,2, Shahin Pourazar Dizaji1,2, Morteza Masoumi1,2, Fatemeh Rahimi Jamnani1,2, Abolfazl Fateh1,2, Seyed Davar Siadat1,2, Farzam Vaziri3,2.   

Abstract

In the regions where bedaquiline (BDQ) is introduced into the regimen, analysis of MIC and screening for preexisting resistance mutations could be crucial. The high prevalence of isolates with high BDQ MICs without prior exposure to BDQ was worrisome. It was also concluded that efflux pumps play a pivotal role in intrinsic BDQ resistance; therefore, the potential of verapamil as an adjunctive therapy to combat BDQ resistance should be investigated.
Copyright © 2019 American Society for Microbiology.

Entities:  

Keywords:  MIC; WGS; bedaquiline; efflux pumps; verapamil

Mesh：

Substances：

Year:  2019        PMID： 30602521      PMCID： PMC6395892          DOI： 10.1128/AAC.02530-18

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  9 in total

1.  Variants in Bedaquiline-Candidate-Resistance Genes: Prevalence in Bedaquiline-Naive Patients, Effect on MIC, and Association with Mycobacterium tuberculosis Lineage.

Authors:  Emmanuel Rivière; Lennert Verboven; Anzaan Dippenaar; Sander Goossens; Elise De Vos; Elizabeth Streicher; Bart Cuypers; Kris Laukens; Fathia Ben-Rached; Timothy C Rodwell; Arnab Pain; Robin M Warren; Tim H Heupink; Annelies Van Rie
Journal:  Antimicrob Agents Chemother       Date:  2022-06-27       Impact factor: 5.938

Review 2.  Are antibacterial effects of non-antibiotic drugs random or purposeful because of a common evolutionary origin of bacterial and mammalian targets?

Authors:  Axel Dalhoff
Journal:  Infection       Date:  2020-12-15       Impact factor: 3.553

Review 3.  Early Drug Development and Evaluation of Putative Antitubercular Compounds in the -Omics Era.

Authors:  Alina Minias; Lidia Żukowska; Ewelina Lechowicz; Filip Gąsior; Agnieszka Knast; Sabina Podlewska; Daria Zygała; Jarosław Dziadek
Journal:  Front Microbiol       Date:  2021-02-02       Impact factor: 5.640

4.  Genetic variants and their association with phenotypic resistance to bedaquiline in Mycobacterium tuberculosis: a systematic review and individual isolate data analysis.

Authors:  Nabila Ismail; Emmanuel Rivière; Jason Limberis; Stella Huo; John Z Metcalfe; Rob M Warren; Annelies Van Rie
Journal:  Lancet Microbe       Date:  2021-08-31

5.  Variants associated with Bedaquiline (BDQ) resistance identified in Rv0678 and efflux pump genes in Mycobacterium tuberculosis isolates from BDQ naïve TB patients in Pakistan.

Authors:  Sadia Shakoor; Safina Abdul Razzak; Dania Khalid Saeed; Zahra Hasan; Saba Faraz Sabzwari; Zahida Azizullah; Akbar Kanji; Asghar Nasir; Samreen Shafiq; Najia Karim Ghanchi; Rumina Hasan
Journal:  BMC Microbiol       Date:  2022-02-25       Impact factor: 3.605

Review 6.  Application of Next Generation Sequencing for Diagnosis and Clinical Management of Drug-Resistant Tuberculosis: Updates on Recent Developments in the Field.

Authors:  Navisha Dookie; Azraa Khan; Nesri Padayatchi; Kogieleum Naidoo
Journal:  Front Microbiol       Date:  2022-03-24       Impact factor: 5.640

7.  Thompson loop: opportunities for antitubercular drug design by targeting the weak spot in demethylmenaquinone methyltransferase protein.

Authors:  Adeniyi T Adewumi; Opeyemi S Soremekun; Mary B Ajadi; Mahmoud E S Soliman
Journal:  RSC Adv       Date:  2020-06-19       Impact factor: 4.036

8.  First report of whole-genome analysis of an extensively drug-resistant Mycobacterium tuberculosis clinical isolate with bedaquiline, linezolid and clofazimine resistance from Uganda.

Authors:  Jupiter Marina Kabahita; Joel Kabugo; Francis Kakooza; Isa Adam; Ocung Guido; Henry Byabajungu; Joanitah Namutebi; Maria Magdalene Namaganda; Pius Lutaaya; James Otim; Fredrick Elishama Kakembo; Stephen Kanyerezi; Patricia Nabisubi; Ivan Sserwadda; George William Kasule; Hasfah Nakato; Kenneth Musisi; Denis Oola; Moses L Joloba; Gerald Mboowa
Journal:  Antimicrob Resist Infect Control       Date:  2022-05-12       Impact factor: 6.454

Review 9.  Whole Genome Sequencing for the Analysis of Drug Resistant Strains of Mycobacterium tuberculosis: A Systematic Review for Bedaquiline and Delamanid.

Authors:  Luisa Maria Nieto Ramirez; Karina Quintero Vargas; Gustavo Diaz
Journal:  Antibiotics (Basel)       Date:  2020-03-23
  9 in total

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