Literature DB >> 30602519

Indole-2-Carboxamides Are Active against Mycobacterium abscessus in a Mouse Model of Acute Infection.

Amit N Pandya1, Pavan K Prathipati2, Pooja Hegde1, Wei Li2, Kyle F Graham1, Subhra Mandal2, Kristen M Drescher3, Christopher J Destache2, Diane Ordway4, Mary Jackson4, E Jeffrey North5.   

Abstract

Nontuberculous mycobacteria (NTM) pathogens particularly infect patients with structural lung disorders. We previously reported novel indole-2-carboxamides (ICs) that are active against a wide panel of NTM pathogens. This study discloses in vivo data for two lead molecules (compounds 5 and 25) that were advanced for efficacy studies in Mycobacterium abscessus-infected mouse models. Oral administration of the lead molecules showed a statistically significant reduction in the bacterial loads in lung and spleen of M. abscessus-infected mice.
Copyright © 2019 American Society for Microbiology.

Entities:  

Keywords:  MmpL3; Mycobacterium; Mycobacterium abscessus; NTM; indole-2-carboxamide; nontuberculous mycobacteria

Mesh：

Substances：

Year:  2019        PMID： 30602519      PMCID： PMC6395937          DOI： 10.1128/AAC.02245-18

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  12 in total

Review 1.  The Many Hosts of Mycobacteria 8 (MHM8): A conference report.

Authors:  Michelle H Larsen; Karen Lacourciere; Tina M Parker; Alison Kraigsley; Jacqueline M Achkar; Linda B Adams; Kathryn M Dupnik; Luanne Hall-Stoodley; Travis Hartman; Carly Kanipe; Sherry L Kurtz; Michele A Miller; Liliana C M Salvador; John S Spencer; Richard T Robinson
Journal:  Tuberculosis (Edinb)       Date:  2020-02-11       Impact factor: 3.131

2.  Proton transfer activity of the reconstituted Mycobacterium tuberculosis MmpL3 is modulated by substrate mimics and inhibitors.

Authors:  Casey M Stevens; Svitlana O Babii; Amitkumar N Pandya; Wei Li; Yupeng Li; Jitender Mehla; Robyn Scott; Pooja Hegde; Pavan K Prathipati; Atanu Acharya; Jinchan Liu; James C Gumbart; Jeffrey North; Mary Jackson; Helen I Zgurskaya
Journal:  Proc Natl Acad Sci U S A       Date:  2022-07-19       Impact factor: 12.779

3.  Synergistic Interactions of Indole-2-Carboxamides and β-Lactam Antibiotics against Mycobacterium abscessus.

Authors:  Clément Raynaud; Wassim Daher; Françoise Roquet-Banères; Matt D Johansen; Jozef Stec; Oluseye K Onajole; Diane Ordway; Alan P Kozikowski; Laurent Kremer
Journal:  Antimicrob Agents Chemother       Date:  2020-04-21       Impact factor: 5.191

Review 4.  Non-tuberculous mycobacteria and the rise of Mycobacterium abscessus.

Authors:  Matt D Johansen; Jean-Louis Herrmann; Laurent Kremer
Journal:  Nat Rev Microbiol       Date:  2020-02-21       Impact factor: 60.633

Review 5.  Pipeline of anti-Mycobacterium abscessus small molecules: Repurposable drugs and promising novel chemical entities.

Authors:  Anna Egorova; Mary Jackson; Victor Gavrilyuk; Vadim Makarov
Journal:  Med Res Rev       Date:  2021-03-01       Impact factor: 12.388

6.  Direct Inhibition of MmpL3 by Novel Antitubercular Compounds.

Authors:  Wei Li; Casey M Stevens; Amitkumar N Pandya; Zbigniew Darzynkiewicz; Pankaj Bhattarai; Weiwei Tong; Mercedes Gonzalez-Juarrero; E Jeffrey North; Helen I Zgurskaya; Mary Jackson
Journal:  ACS Infect Dis       Date:  2019-03-28       Impact factor: 5.084

Review 7.  Mycobacterium abscessus, an Emerging and Worrisome Pathogen among Cystic Fibrosis Patients.

Authors:  Giulia Degiacomi; José Camilla Sammartino; Laurent Roberto Chiarelli; Olga Riabova; Vadim Makarov; Maria Rosalia Pasca
Journal:  Int J Mol Sci       Date:  2019-11-22       Impact factor: 5.923

Review 8.  Alternative and Experimental Therapies of Mycobacterium abscessus Infections.

Authors:  Michal Meir; Daniel Barkan
Journal:  Int J Mol Sci       Date:  2020-09-16       Impact factor: 5.923

9.  Two-Way Regulation of MmpL3 Expression Identifies and Validates Inhibitors of MmpL3 Function in Mycobacterium tuberculosis.

Authors:  Shipra Grover; Curtis A Engelhart; Esther Pérez-Herrán; Wei Li; Katherine A Abrahams; Kadamba Papavinasasundaram; James M Bean; Christopher M Sassetti; Alfonso Mendoza-Losana; Gurdyal S Besra; Mary Jackson; Dirk Schnappinger
Journal:  ACS Infect Dis       Date:  2020-12-15       Impact factor: 5.084

10.  Genome-Wide Essentiality Analysis of Mycobacterium abscessus by Saturated Transposon Mutagenesis and Deep Sequencing.

Authors:  Dalin Rifat; Liang Chen; Barry N Kreiswirth; Eric L Nuermberger
Journal:  mBio       Date:  2021-06-15       Impact factor: 7.867
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