Haibin Zhao1,2,3, Hui Liu1,2,3, Mei Li1,2,3, Shuiying Ma1,2,3, Cheng Li1,2,3, Keliang Wu4,5,6. 1. Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China. 2. National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, China. 3. The Key laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, China. 4. Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China, wukeliang_527@163.com. 5. National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, China, wukeliang_527@163.com. 6. The Key laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, China, wukeliang_527@163.com.
Abstract
BACKGROUND/AIM: To compare the clinical outcomes between > 10- and 8-cell good quality embryos on day 3. METHODS: A retrospective study of a cohort of 459 patients was included in the fresh embryo transfer (ET) cycle group from January 2009 to April 2016. In this group, 2 good quality embryos on day 3, were transferred on corresponding dates, in 75 patients (> 10-cell embryos), and in 384 patients (8-cell embryos). Seven hundred and forty four patients, with 1 blastocyst transferred derived from > 10-cell (n = 183) or 8-cell (n = 561) good quality embryos on day 3, were assigned in the frozen ET (FET) group. RESULTS: In the ET group, the clinical pregnancy and live birth rates of the > 10-cell transfer patients were comparable with those of the 8-cell transfer group (62.67 vs. 69.27%, 60.00 vs. 59.90%, respectively); however, the miscarriage rate of > 10-cell transfers was significantly lower than that of 8-cell transfers (4.26 vs. 13.53%, p < 0.05). In the FET group, there were no statistically significant differences found in the clinical pregnancy, live birth, and miscarriage rates between one > 10-cell-derived and one 8-cell-derived blastocyst transfers (71.04 vs. 65.78%, 59.02 vs. 54.19%, and 16.92 vs. 17.62%, respectively). CONCLUSIONS: The results suggested that > 10- and 8-cell, good quality embryos on day 3, had comparable viability and clinical outcomes.
BACKGROUND/AIM: To compare the clinical outcomes between > 10- and 8-cell good quality embryos on day 3. METHODS: A retrospective study of a cohort of 459 patients was included in the fresh embryo transfer (ET) cycle group from January 2009 to April 2016. In this group, 2 good quality embryos on day 3, were transferred on corresponding dates, in 75 patients (> 10-cell embryos), and in 384 patients (8-cell embryos). Seven hundred and forty four patients, with 1 blastocyst transferred derived from > 10-cell (n = 183) or 8-cell (n = 561) good quality embryos on day 3, were assigned in the frozen ET (FET) group. RESULTS: In the ET group, the clinical pregnancy and live birth rates of the > 10-cell transfer patients were comparable with those of the 8-cell transfer group (62.67 vs. 69.27%, 60.00 vs. 59.90%, respectively); however, the miscarriage rate of > 10-cell transfers was significantly lower than that of 8-cell transfers (4.26 vs. 13.53%, p < 0.05). In the FET group, there were no statistically significant differences found in the clinical pregnancy, live birth, and miscarriage rates between one > 10-cell-derived and one 8-cell-derived blastocyst transfers (71.04 vs. 65.78%, 59.02 vs. 54.19%, and 16.92 vs. 17.62%, respectively). CONCLUSIONS: The results suggested that > 10- and 8-cell, good quality embryos on day 3, had comparable viability and clinical outcomes.