| Literature DB >> 30601550 |
Catherine Au1, Christina Gonzalez, Yun Cheuk Leung, Flora Mansour, Johny Trinh, Zhiyong Wang, Xiang-Guo Hu, Renate Griffith, Eddy Pasquier, Luke Hunter.
Abstract
Stereoselective fluorination is investigated as a method for modulating the properties of a cyclic RGD-containing tetrapeptide. Three key outcomes of fluorination are assessed: (i) the effect on peptide cyclisation efficiency; (ii) the ability to fine-tune the molecular conformation; and (iii) the effect on the cyclic peptides' biological activity. Fluorination is found to exert pronounced effects against all three criteria.Year: 2019 PMID： 30601550 DOI： 10.1039/c8ob02679c
Source DB: PubMed Journal: Org Biomol Chem ISSN： 1477-0520 Impact factor: 3.876