| Literature DB >> 30600580 |
Wilfried Mullens1,2, Kevin Damman3, Veli-Pekka Harjola4, Alexandre Mebazaa5, Hans-Peter Brunner-La Rocca6, Pieter Martens1,2, Jeffrey M Testani7, W H Wilson Tang8, Francesco Orso9, Patrick Rossignol10, Marco Metra11, Gerasimos Filippatos12,13, Petar M Seferovic14, Frank Ruschitzka15, Andrew J Coats16.
Abstract
The vast majority of acute heart failure episodes are characterized by increasing symptoms and signs of congestion with volume overload. The goal of therapy in those patients is the relief of congestion through achieving a state of euvolaemia, mainly through the use of diuretic therapy. The appropriate use of diuretics however remains challenging, especially when worsening renal function, diuretic resistance and electrolyte disturbances occur. This position paper focuses on the use of diuretics in heart failure with congestion. The manuscript addresses frequently encountered challenges, such as (i) evaluation of congestion and clinical euvolaemia, (ii) assessment of diuretic response/resistance in the treatment of acute heart failure, (iii) an approach towards stepped pharmacologic diuretic strategies, based upon diuretic response, and (iv) management of common electrolyte disturbances. Recommendations are made in line with available guidelines, evidence and expert opinion.Entities:
Keywords: Acute heart failure; Diuretics; Heart failure; Loop diuretics; Pharmacotherapy
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Year: 2019 PMID: 30600580 DOI: 10.1002/ejhf.1369
Source DB: PubMed Journal: Eur J Heart Fail ISSN: 1388-9842 Impact factor: 15.534