Mohamed Khalis1, Véronique Chajès2, Aurelie Moskal2, Carine Biessy2, Inge Huybrechts2, Sabina Rinaldi2, Laure Dossus2, Hafida Charaka3, Nawfel Mellas4, Chakib Nejjari5, Joan Dorn6, Amr S Soliman6, Isabelle Romieu2, Karima El Rhazi7, Barbara Charbotel8. 1. Department of Epidemiology, Faculty of Medicine and Pharmacy, Fez, Morocco; University of Lyon, UCBL, Ifsttar, UMRESTTE, Lyon, France; Department of Community Health and Social Medicine, City University of New York, School of Medicine, NY, USA. Electronic address: khalis.mohamed79@gmail.com. 2. Nutrition and Metabolism Section, International Agency for Research on Cancer, Lyon, France. 3. Department of Research and Development, Hassan II University Hospital of Fez, Morocco. 4. Department of Oncology, Hassan II University Hospital of Fez, Morocco. 5. Mohammed VI University of Health Sciences, Casablanca, Morocco. 6. Department of Community Health and Social Medicine, City University of New York, School of Medicine, NY, USA. 7. Department of Epidemiology, Faculty of Medicine and Pharmacy, Fez, Morocco. 8. University of Lyon, UCBL, Ifsttar, UMRESTTE, Lyon, France.
Abstract
BACKGROUND: Some modifiable risk factors have been independently associated with breast cancer (BC) risk in Moroccan women, but no studies have investigated their joint association. This study aimed to investigate the association between a Healthy Lifestyle Index (HLI) score and BC risk among Moroccan women. METHODS: In this case-control study, 300 incident BC cases and 300 controls, matched by age and area of residence were recruited. Cases were women newly-diagnosed with histopathologically-confirmed BC at the University Hospital in Fez, Morocco. Controls were randomly selected healthy women recruited from 6 primary health centers in Fez. HLI scores developed within this study were assigned to participants based on 11 factors (red and processed meat, white meat, cream, cheese, fish, fruit and vegetables, physical activity, BMI, smoking, alcohol consumption, and breastfeeding), where 0 was given to unhealthy and 0.5 or 1 to healthy levels of each factor. Conditional and unconditional logistic regression models were used to assess the association between HLI scores and BC risk. RESULTS: Mean of HLI scores were 8.1 (±1.1) and 9.0 (±0.9) in cases and controls, respectively, p < 0.01. After adjusting for potential confounders, one-point increment in the HLI score was associated with 56% (95% CI, CI: 39-68%), 49% (95% CI: 30-63%), and 59% (95% CI: 40-72%) lower risks of BC in all, premenopausal, and postmenopausal women, respectively. CONCLUSION: High HLI scores were associated with decreased risk of BC in Moroccan women. These findings suggest that BC prevention policies should include strategies for engaging Moroccan women in healthy lifestyles.
BACKGROUND: Some modifiable risk factors have been independently associated with breast cancer (BC) risk in Moroccan women, but no studies have investigated their joint association. This study aimed to investigate the association between a Healthy Lifestyle Index (HLI) score and BC risk among Moroccan women. METHODS: In this case-control study, 300 incident BC cases and 300 controls, matched by age and area of residence were recruited. Cases were women newly-diagnosed with histopathologically-confirmed BC at the University Hospital in Fez, Morocco. Controls were randomly selected healthy women recruited from 6 primary health centers in Fez. HLI scores developed within this study were assigned to participants based on 11 factors (red and processed meat, white meat, cream, cheese, fish, fruit and vegetables, physical activity, BMI, smoking, alcohol consumption, and breastfeeding), where 0 was given to unhealthy and 0.5 or 1 to healthy levels of each factor. Conditional and unconditional logistic regression models were used to assess the association between HLI scores and BC risk. RESULTS: Mean of HLI scores were 8.1 (±1.1) and 9.0 (±0.9) in cases and controls, respectively, p < 0.01. After adjusting for potential confounders, one-point increment in the HLI score was associated with 56% (95% CI, CI: 39-68%), 49% (95% CI: 30-63%), and 59% (95% CI: 40-72%) lower risks of BC in all, premenopausal, and postmenopausal women, respectively. CONCLUSION: High HLI scores were associated with decreased risk of BC in Moroccan women. These findings suggest that BC prevention policies should include strategies for engaging Moroccan women in healthy lifestyles.
Authors: Qian Li; Corina Lesseur; Alfred I Neugut; Regina M Santella; Humberto Parada; Susan Teitelbaum; Jia Chen Journal: Breast Cancer Date: 2022-06-03 Impact factor: 3.307
Authors: Firas S Azzeh; Deena M Hasanain; Alaa H Qadhi; Khloud J Ghafouri; Wedad F Azhar; Mazen M Ghaith; Abdullah F Aldairi; Hussain A Almasmoum; Hamza M Assaggaf; Maha H Alhussain; Ahmad A Alghamdi; Mahmoud M Habibullah; Waleed M Bawazir; Sofyan S Maghaydah; Maysoun S Qutob; Awfa Y Alazzeh Journal: Front Nutr Date: 2022-04-18