Tino Prell1, Nayana Gaur2, Beatrice Stubendorff2, Annekathrin Rödiger2, Otto W Witte3, Julian Grosskreutz3. 1. Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany; Center for Healthy Ageing, Jena University Hospital, Jena, Germany. Electronic address: Tino.prell@med.uni-jena.de. 2. Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany. 3. Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany; Center for Healthy Ageing, Jena University Hospital, Jena, Germany.
Abstract
OBJECTIVES: To determine the impact of disease progression on health-related quality of life in amyotrophic lateral sclerosis (ALS). METHODS: A total of 161 patients with ALS were enrolled. Assessments included the revised ALS Functional Rating Scale and the ALS Assessment Questionnaire (ALSAQ-40). Data analysis comprised linear regression and multivariate analyses. RESULTS: ALSFRS-R score (β = 0.75, p < 0.001), depression (β = 0.08, p < 0.001), pain (β = 0.07, p < 0.001), hopelessness (β = 0.07, p = 0.001), and progression rate (β = 0.02, p = 0.02) explained 76% of the ALSAQ-40 summary index variance. Progression rate alone explained 7% of the ALSAQ-40 summary index variance. The subdomains of emotional well-being, followed by ADL, and finally communication and eating were most strongly influenced by progression rate. CONCLUSION: Our study demonstrates the importance of physical health for emotional well-being. In particular, slower disease progression is associated with higher levels of emotional well-being in ALS.
OBJECTIVES: To determine the impact of disease progression on health-related quality of life in amyotrophic lateral sclerosis (ALS). METHODS: A total of 161 patients with ALS were enrolled. Assessments included the revised ALS Functional Rating Scale and the ALS Assessment Questionnaire (ALSAQ-40). Data analysis comprised linear regression and multivariate analyses. RESULTS: ALSFRS-R score (β = 0.75, p < 0.001), depression (β = 0.08, p < 0.001), pain (β = 0.07, p < 0.001), hopelessness (β = 0.07, p = 0.001), and progression rate (β = 0.02, p = 0.02) explained 76% of the ALSAQ-40 summary index variance. Progression rate alone explained 7% of the ALSAQ-40 summary index variance. The subdomains of emotional well-being, followed by ADL, and finally communication and eating were most strongly influenced by progression rate. CONCLUSION: Our study demonstrates the importance of physical health for emotional well-being. In particular, slower disease progression is associated with higher levels of emotional well-being in ALS.
Authors: Emma M Devenney; Kate McErlean; Nga Yan Tse; Jashelle Caga; Thanuja Dharmadasa; William Huynh; Colin J Mahoney; Margaret Zoing; Srestha Mazumder; Carol Dobson-Stone; John B Kwok; Glenda M Halliday; John R Hodges; Olivier Piguet; Rebekah M Ahmed; Matthew C Kiernan Journal: Front Neurol Date: 2021-11-25 Impact factor: 4.003