Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Expression of human T-lymphocyte antigens by natural killer cells.

Literature DB >> 305967

Expression of human T-lymphocyte antigens by natural killer cells.

Abstract

Rabbit antisera against human T-lymphocyte and B-lymphocyte antigens (anti-HTLA and anti-HBLA, respectively) were used to characterize natural killer (NK) cells mediating spontaneous cell-mediated cytotoxicity for myelogenous leukemia cell line K562 as measured in a 51Cr-release assay. NK activity of lymphocyte suspensions was abrogated by incubation of the suspensions in anti-HTLA plus complement but not by incubation in anti-HBLA plus complement. The effect of anti-HTLA was due to removal of NK cells rather than antigen-antibody complex inhibition of NK cells inasmuch as lytic complement was necessary. The results indicated that NK cells were HTLA+-HBLA- and thus supported the concept that NK cells are T-cells.

Entities: Disease Species

Mesh：

Substances：

Year: 1978 PMID： 305967 DOI： 10.1093/jnci/60.5.961

Source DB: PubMed Journal: J Natl Cancer Inst ISSN： 0027-8874 Impact factor: 13.506

Keyword Cloud
Cited

12 in total

Review 1. Lymphocyte-mediated lysis of tumor cells in vitro. Antigen-restricted clonal and unrestricted polyclonal effects.

Authors: E Klein
Journal: Springer Semin Immunopathol Date: 1982

Review 2. Natural killer cells: artifact to reality: an odyssey in biology.

Authors: R K Oldham
Journal: Cancer Metastasis Rev Date: 1983 Impact factor: 9.264

3. Lymphocyte-mediated cytotoxicity against allogeneic tumour cells. IV. Fine specificity mapping and characterization of concanavalin A-activated cytotoxic effector lymphocytes.

Authors: J D Waterfield; D F Nixon; M G Mair
Journal: Immunology Date: 1981-12 Impact factor: 7.397

4. Natural killing and growth inhibition of K562 cells by subpopulations of mononuclear cells as a function of target cell proliferation.

Authors: G Hagner
Journal: Immunology Date: 1984-07 Impact factor: 7.397

5. Proliferation of T gamma-lymphocytes in two patients: clinical features and functional properties of the proliferating cells.

Authors: G Schlimok; E Thiel; E P Rieber; D Huhn; H Feucht; D Renner; G Riethmüller
Journal: Klin Wochenschr Date: 1982-02-01

6. Spontaneous lymphocyte-mediated (NK cell) cytotoxicity in systemic sclerosis: a comparison with antibody-dependent lymphocyte (K cell) cytotoxicity.

Authors: J K Wright; P Hughes; N R Rowell
Journal: Ann Rheum Dis Date: 1982-08 Impact factor: 19.103

Expression of human T-lymphocyte antigens by natural killer cells.

Review 1. Lymphocyte-mediated lysis of tumor cells in vitro. Antigen-restricted clonal and unrestricted polyclonal effects.

Review 2. Natural killer cells: artifact to reality: an odyssey in biology.

3. Lymphocyte-mediated cytotoxicity against allogeneic tumour cells. IV. Fine specificity mapping and characterization of concanavalin A-activated cytotoxic effector lymphocytes.

4. Natural killing and growth inhibition of K562 cells by subpopulations of mononuclear cells as a function of target cell proliferation.

5. Proliferation of T gamma-lymphocytes in two patients: clinical features and functional properties of the proliferating cells.

6. Spontaneous lymphocyte-mediated (NK cell) cytotoxicity in systemic sclerosis: a comparison with antibody-dependent lymphocyte (K cell) cytotoxicity.

7. Susceptibility of human leukaemias to cell-mediated cytotoxicity by interferon-treated allogeneic lymphocytes.

8. Target selectivity of interferon-induced human killer lymphocytes related to their Fc receptor expression.

9. Isolation of human spontaneous killer lymphocytes by bacterial adherence.

10. The origin of human NK cells. An ontogenic model derived from studies in patients with immunodeficiencies.