Literature DB >> 30596342

Transcriptome protection by the expanded family of hnRNPs.

Urmi Das1, Hai Nguyen1,2, Jiuyong Xie1.   

Abstract

The family of heterogeneous ribonucleoproteins (hnRNPs) have multiple functions in RNA metabolism. In recent years, several hnRNPs have also been shown to be essential for the maintenance of transcriptome integrity, by preventing intronic cryptic splicing signals from mis-splicing of many endogeneous pre-mRNA transcripts. Here we discuss the possibility for a general role of this family of proteins and their expansion in transcriptome protection.

Keywords:  Hnrnps; cryptic splicing; introns; transcriptome integrity

Mesh：

Substances：

Year:  2019        PMID： 30596342      PMCID： PMC6380323          DOI： 10.1080/15476286.2018.1564617

Source DB:  PubMed          Journal:  RNA Biol        ISSN： 1547-6286            Impact factor:   4.652


  58 in total

1.  Conformation of polypyrimidine tract binding protein in solution.

Authors:  Maxim V Petoukhov; Tom P Monie; Frédéric H-T Allain; Stephen Matthews; Stephen Curry; Dmitri I Svergun
Journal:  Structure       Date:  2006-06       Impact factor: 5.006

2.  Differential alternative splicing activity of isoforms of polypyrimidine tract binding protein (PTB).

Authors:  M C Wollerton; C Gooding; F Robinson; E C Brown; R J Jackson; C W Smith
Journal:  RNA       Date:  2001-06       Impact factor: 4.942

3.  A mutation (IVS8+0.6kbdelTC) creating a new donor splice site activates a cryptic exon in an Alu-element in intron 8 of the human beta-glucuronidase gene.

Authors:  R Vervoort; R Gitzelmann; W Lissens; I Liebaers
Journal:  Hum Genet       Date:  1998-12       Impact factor: 4.132

4.  Cancer-Associated SF3B1 Hotspot Mutations Induce Cryptic 3' Splice Site Selection through Use of a Different Branch Point.

Authors:  Rachel B Darman; Michael Seiler; Anant A Agrawal; Kian H Lim; Shouyong Peng; Daniel Aird; Suzanna L Bailey; Erica B Bhavsar; Betty Chan; Simona Colla; Laura Corson; Jacob Feala; Peter Fekkes; Kana Ichikawa; Gregg F Keaney; Linda Lee; Pavan Kumar; Kaiko Kunii; Crystal MacKenzie; Mark Matijevic; Yoshiharu Mizui; Khin Myint; Eun Sun Park; Xiaoling Puyang; Anand Selvaraj; Michael P Thomas; Jennifer Tsai; John Y Wang; Markus Warmuth; Hui Yang; Ping Zhu; Guillermo Garcia-Manero; Richard R Furman; Lihua Yu; Peter G Smith; Silvia Buonamici
Journal:  Cell Rep       Date:  2015-10-22       Impact factor: 9.423

5.  Immunopurification of heterogeneous nuclear ribonucleoprotein particles reveals an assortment of RNA-binding proteins.

Authors:  S Piñol-Roma; Y D Choi; M J Matunis; G Dreyfuss
Journal:  Genes Dev       Date:  1988-02       Impact factor: 11.361

6.  U1 snRNP determines mRNA length and regulates isoform expression.

Authors:  Michael G Berg; Larry N Singh; Ihab Younis; Qiang Liu; Anna Maria Pinto; Daisuke Kaida; Zhenxi Zhang; Sungchan Cho; Scott Sherrill-Mix; Lili Wan; Gideon Dreyfuss
Journal:  Cell       Date:  2012-07-06       Impact factor: 41.582

7.  HnRNP L and hnRNP LL antagonistically modulate PTB-mediated splicing suppression of CHRNA1 pre-mRNA.

Authors:  Mohammad Alinoor Rahman; Akio Masuda; Kenji Ohe; Mikako Ito; David O Hutchinson; Akila Mayeda; Andrew G Engel; Kinji Ohno
Journal:  Sci Rep       Date:  2013-10-14       Impact factor: 4.379

8.  Competitive regulation of alternative splicing and alternative polyadenylation by hnRNP H and CstF64 determines acetylcholinesterase isoforms.

Authors:  Mohammad Nazim; Akio Masuda; Mohammad Alinoor Rahman; Farhana Nasrin; Jun-Ichi Takeda; Kenji Ohe; Bisei Ohkawara; Mikako Ito; Kinji Ohno
Journal:  Nucleic Acids Res       Date:  2017-02-17       Impact factor: 16.971

9.  A pan-cancer analysis of transcriptome changes associated with somatic mutations in U2AF1 reveals commonly altered splicing events.

Authors:  Angela N Brooks; Peter S Choi; Luc de Waal; Tanaz Sharifnia; Marcin Imielinski; Gordon Saksena; Chandra Sekhar Pedamallu; Andrey Sivachenko; Mara Rosenberg; Juliann Chmielecki; Michael S Lawrence; David S DeLuca; Gad Getz; Matthew Meyerson
Journal:  PLoS One       Date:  2014-01-31       Impact factor: 3.240

10.  HnRNP L represses cryptic exons.

Authors:  Sean P McClory; Kristen W Lynch; Jonathan P Ling
Journal:  RNA       Date:  2018-03-26       Impact factor: 4.942
View more
  5 in total

1.  Genome-wide evolution of wobble base-pairing nucleotides of branchpoint motifs with increasing organismal complexity.

Authors:  Hai Nguyen; Urmi Das; Jiuyong Xie
Journal:  RNA Biol       Date:  2019-12-19       Impact factor: 4.652

2.  Long non-coding RNA lincRNA-erythroid prosurvival (EPS) alleviates cerebral ischemia/reperfusion injury by maintaining high-temperature requirement protein A1 (Htra1) stability through recruiting heterogeneous nuclear ribonucleoprotein L (HNRNPL).

Authors:  Haifeng Guo; Xia Guo; Shiting Jiang
Journal:  Bioengineered       Date:  2022-05       Impact factor: 6.832

3.  hnRNP L is essential for myogenic differentiation and modulates myotonic dystrophy pathologies.

Authors:  Matthew S Alexander; Rylie M Hightower; Andrea L Reid; Alexis H Bennett; Lakshmanan Iyer; Donna K Slonim; Madhurima Saha; Genri Kawahara; Louis M Kunkel; Alan S Kopin; Vandana A Gupta; Peter B Kang; Isabelle Draper
Journal:  Muscle Nerve       Date:  2021-03-22       Impact factor: 3.852

4.  The hnRNPK/A1/R/U Complex Regulates Gene Transcription and Translation and is a Favorable Prognostic Biomarker for Human Colorectal Adenocarcinoma.

Authors:  Yixin Li; Hui Wang; Jiajia Wan; Qian Ma; Yu Qi; Zhuoyu Gu
Journal:  Front Oncol       Date:  2022-07-07       Impact factor: 5.738

5.  Functional diversity of small nucleolar RNAs.

Authors:  Tomaž Bratkovič; Janja Božič; Boris Rogelj
Journal:  Nucleic Acids Res       Date:  2020-02-28       Impact factor: 16.971
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.