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Literature DB >> 30595649

Manganese Transport into the Brain: Putative Mechanisms.

Michael Aschner¹, Ana Paula Marreilha Dos Santos², Keith M Erikson³, Wei Zheng⁴.

Abstract

An important process in the toxicologic outcome of exposure to metals is their transport from plasma into the brain across the capillary endothelial cells that comprise the blood-brain barrier (BBB). The review, briefly delineates the known transport mechanisms of manganese (Mn) across the BBB, a crucial step in Mn accumulation in the brain. Herein, we discuss the distribution of Mn in the central nervous system (CNS) and identify putative transport mechanism for Mn, emphasize the close chemical interaction between Mn and iron (Fe) and the role of transferrin (Tf) and divalent metal transport1 (DMT1) in this process.

Entities: Chemical Gene

Keywords: Divalent Metal Transporter1 (DMT1); Iron (Fe); Manganese (Mn); Parkison’s disease; Transferrin (Tf)

Year: 2008 PMID： 30595649 PMCID： PMC6309952

Source DB: PubMed Journal: Met Ions Biol Med ISSN： 1257-2535

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References

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Manganese Transport into the Brain: Putative Mechanisms.

1. Occupational exposure to manganese, copper, lead, iron, mercury and zinc and the risk of Parkinson's disease.

Review 2. Effects from environmental Mn exposures: a review of the evidence from non-occupational exposure studies.

3. Differential localization of divalent metal transporter 1 with and without iron response element in rat PC12 and sympathetic neuronal cells.

Review 4. Occupational metal exposures and the risk of Parkinson's disease.

5. Manganese concentration in mouse brain after intravenous injection.

6. Iron and manganese homeostasis in chronic liver disease: relationship to pallidal T1-weighted magnetic resonance signal hyperintensity.

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