Sarah Maheux-Lacroix1, Catherine Bergeron2, Lynne Moore2, Marie-Ève Bergeron3, Jessica Lefebvre4, Iseult Grenier-Ouellette2, Sylvie Dodin3. 1. Department of Obstetrics and Gynecology, Centre Hospitalier Universitaire de Québec-Université Laval, Québec, QC; Centre Hospitalier Universitaire de Québec-Université Laval Research Centre, Québec, QC. Electronic address: sarah.maheux-lacroix@crchudequebec.ulaval.ca. 2. Centre Hospitalier Universitaire de Québec-Université Laval Research Centre, Québec, QC. 3. Department of Obstetrics and Gynecology, Centre Hospitalier Universitaire de Québec-Université Laval, Québec, QC; Centre Hospitalier Universitaire de Québec-Université Laval Research Centre, Québec, QC. 4. Department of Obstetrics and Gynecology, Centre Hospitalier Universitaire de Québec-Université Laval, Québec, QC.
Abstract
OBJECTIVE: This study sought to examine whether hysterosalpingosonography (sono-HSG) is as effective as hysterosalpingography (HSG) in facilitating conception by comparing pregnancy rates in the 6 months following the procedures. METHODS: This retrospective noninferiority study (Canadian Task Force classification II-2) was conducted at a tertiary university centre. The investigators studied 440 consecutive eligible infertile women. Bilateral tubal occlusion, severe male infertility, and having undergone both procedures were exclusion criteria. Tubal testing, as part of the infertility workup, was performed by either sono-HSG or HSG. The primary outcome was pregnancy, defined as a positive fetal heartbeat on ultrasonographic examination, in the 6 months following the procedure. RESULTS: A total of 57 pregnancies (26%) were observed in the HSG group and 33 (15%) in the sono-HSG group. Adjusted and non-adjusted relative risks of pregnancy in the 6 months following sono-HSG compared with HSG were 0.61 (95% CI 0.42-0.89) and 0.58 (95% CI 0.39-0.85). Adverse events were infrequent with both procedures (sono-HSG, 1%; HSG, 4%; P = 0.16). CONCLUSION: This study suggests that uterine flushing as performed during sono-HSG is not as effective as when performed during HSG to increase the chances of pregnancy, but further studies will be required because of bias related to the retrospective study design.
OBJECTIVE: This study sought to examine whether hysterosalpingosonography (sono-HSG) is as effective as hysterosalpingography (HSG) in facilitating conception by comparing pregnancy rates in the 6 months following the procedures. METHODS: This retrospective noninferiority study (Canadian Task Force classification II-2) was conducted at a tertiary university centre. The investigators studied 440 consecutive eligible infertile women. Bilateral tubal occlusion, severe male infertility, and having undergone both procedures were exclusion criteria. Tubal testing, as part of the infertility workup, was performed by either sono-HSG or HSG. The primary outcome was pregnancy, defined as a positive fetal heartbeat on ultrasonographic examination, in the 6 months following the procedure. RESULTS: A total of 57 pregnancies (26%) were observed in the HSG group and 33 (15%) in the sono-HSG group. Adjusted and non-adjusted relative risks of pregnancy in the 6 months following sono-HSG compared with HSG were 0.61 (95% CI 0.42-0.89) and 0.58 (95% CI 0.39-0.85). Adverse events were infrequent with both procedures (sono-HSG, 1%; HSG, 4%; P = 0.16). CONCLUSION: This study suggests that uterine flushing as performed during sono-HSG is not as effective as when performed during HSG to increase the chances of pregnancy, but further studies will be required because of bias related to the retrospective study design.
Authors: Khawaja B Waheed; Muneera A Albassam; Alaa-Ali G AlShamrani; Shayma A Aloumi; Muhammad S Amin; Lubna Rashid; Sarah M AlGodayan; Siti-Fatimah B Ahmad Journal: Saudi Med J Date: 2019-10 Impact factor: 1.484