Literature DB >> 30594925

Glial Fibrillary Acidic Protein in Serum is Increased in Alzheimer's Disease and Correlates with Cognitive Impairment.

Patrick Oeckl1, Steffen Halbgebauer1, Sarah Anderl-Straub1, Petra Steinacker1, André M Huss1, Hermann Neugebauer1, Christine A F von Arnim1, Janine Diehl-Schmid2, Timo Grimmer2, Johannes Kornhuber3, Piotr Lewczuk3,4, Adrian Danek5, Albert C Ludolph1, Markus Otto1.   

Abstract

Reliable blood biomarkers for Alzheimer's disease (AD) are missing. We measured astroglial GFAP in patients with AD (n = 28), frontotemporal dementia (bvFTD, n = 35), Parkinson's disease (n = 11), Lewy body dementias (n = 19), and controls (n = 34). Serum GFAP was increased in AD (p < 0.001) and DLB/PDD (p < 0.01), and cerebrospinal fluid GFAP was increased in all neurodegenerative diseases (p < 0.001). Serum GFAP correlated with the Mini-Mental State Examination score (r= -0.42, p < 0.001) and might be a follow-up marker in clinical trials. Sensitivity and specificity of serum GFAP for AD versus bvFTD was 89% and 79% and might be the first blood biomarker in the differential diagnosis of AD and bvFTD.

Entities:  

Keywords:  Alzheimer’s disease; GFAP; Lewy body dementia; Parkinson’s disease; astrocyte; biomarker; cerebrospinal fluid; differential diagnosis; frontotemporal dementia; serum

Mesh：

Substances：

Year:  2019        PMID： 30594925     DOI： 10.3233/JAD-180325

Source DB:  PubMed          Journal:  J Alzheimers Dis        ISSN： 1387-2877            Impact factor:   4.472


  56 in total

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Authors:  Donovan A McGrowder; Fabian Miller; Kurt Vaz; Chukwuemeka Nwokocha; Cameil Wilson-Clarke; Melisa Anderson-Cross; Jabari Brown; Lennox Anderson-Jackson; Lowen Williams; Lyndon Latore; Rory Thompson; Ruby Alexander-Lindo
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2.  Astrocyte biomarker signatures of amyloid-β and tau pathologies in Alzheimer's disease.

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Journal:  Mol Psychiatry       Date:  2022-08-10       Impact factor: 13.437

3.  Examining the association between blood-based biomarkers and human post mortem neuropathology in the University of Kentucky Alzheimer's Disease Research Center autopsy cohort.

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Journal:  Alzheimers Dement       Date:  2022-03-10       Impact factor: 16.655

4.  Different Inflammatory Signatures in Alzheimer's Disease and Frontotemporal Dementia Cerebrospinal Fluid.

Authors:  Gustaf Boström; Eva Freyhult; Johan Virhammar; Daniel Alcolea; Hayrettin Tumani; Markus Otto; Rose-Marie Brundin; Lena Kilander; Malin Löwenmark; Vilmantas Giedraitis; Alberto Lleó; Christine A F von Arnim; Kim Kultima; Martin Ingelsson
Journal:  J Alzheimers Dis       Date:  2021       Impact factor: 4.472

5.  Astrogliosis and episodic memory in late life: higher GFAP is related to worse memory and white matter microstructure in healthy aging and Alzheimer's disease.

Authors:  Brianne M Bettcher; Kaitlin E Olson; Nichole E Carlson; Brice V McConnell; Tim Boyd; Vanesa Adame; D Adriana Solano; Paige Anton; Neil Markham; Ashesh A Thaker; Alexandria M Jensen; Erika N Dallmann; Huntington Potter; Christina Coughlan
Journal:  Neurobiol Aging       Date:  2021-02-26       Impact factor: 5.133

6.  Why Inclusion Matters for Alzheimer's Disease Biomarker Discovery in Plasma.

Authors:  Mostafa J Khan; Heather Desaire; Oscar L Lopez; M Ilyas Kamboh; Renã A S Robinson
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7.  Systematic Review: Genetic, Neuroimaging, and Fluids Biomarkers for Frontotemporal Dementia Across Latin America Countries.

Authors:  Claudia Duran-Aniotz; Paulina Orellana; Tomas Leon Rodriguez; Fernando Henriquez; Victoria Cabello; María F Aguirre-Pinto; Tamara Escobedo; Leonel T Takada; Stefanie D Pina-Escudero; Oscar Lopez; Jennifer S Yokoyama; Agustin Ibanez; Mario A Parra; Andrea Slachevsky
Journal:  Front Neurol       Date:  2021-06-24       Impact factor: 4.003

8.  Bone marrow mesenchymal stem cells and their derived exosomes resolve doxorubicin-induced chemobrain: critical role of their miRNA cargo.

Authors:  Marwa O El-Derany; Mohamed H Noureldein
Journal:  Stem Cell Res Ther       Date:  2021-06-05       Impact factor: 6.832

9.  Lower White Matter Volume and Worse Executive Functioning Reflected in Higher Levels of Plasma GFAP among Older Adults with and Without Cognitive Impairment.

Authors:  Breton M Asken; Lawren VandeVrede; Julio C Rojas; Corrina Fonseca; Adam M Staffaroni; Fanny M Elahi; Cutter A Lindbergh; Alexandra C Apple; Michelle You; Sophia Weiner-Light; Nivetha Brathaban; Nicole Fernandes; Adam L Boxer; Bruce L Miller; Howie J Rosen; Joel H Kramer; Kaitlin B Casaletto
Journal:  J Int Neuropsychol Soc       Date:  2021-06-22       Impact factor: 3.114

10.  Remote Blood Biomarkers of Longitudinal Cognitive Outcomes in a Population Study.

Authors:  Kumar B Rajan; Neelum T Aggarwal; Elizabeth A McAninch; Jennifer Weuve; Lisa L Barnes; Robert S Wilson; Charles DeCarli; Denis A Evans
Journal:  Ann Neurol       Date:  2020-09-29       Impact factor: 11.274
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