Jose R Suarez-Lopez1, Chase G Clemesha2, Miquel Porta3, Myron D Gross4, Duk-Hee Lee5. 1. Department of Family Medicine and Public Health, University of California, 9500 Gilman Drive #0725, La Jolla, San Diego, CA 92093-0725, USA. Electronic address: jrsuarez@ucsd.edu. 2. Department of Family Medicine and Public Health, University of California, 9500 Gilman Drive #0725, La Jolla, San Diego, CA 92093-0725, USA. Electronic address: clemesha@ucsd.edu. 3. Hospital del Mar Institute of Medical Research (IMIM), School of Medicine, Universitat Autonoma de Barcelona, and CIBERESP, Carrer del Dr. Aiguader, 88, E-08003 Barcelona, Catalonia, Spain. Electronic address: mporta@imim.es. 4. Department of Laboratory Medicine and Pathology, University of Minnesota, MMC 609 Mayo 8609, 420 Delaware, Minneapolis, MN 55455, USA. Electronic address: gross001@umn.edu. 5. Department of Preventive Medicine, School of Medicine, Kyungpook National University, 101 Dongin-dong, Jung-gu, Daegu, 700-422, Republic of Korea. Electronic address: lee_dh@knu.ac.kr.
Abstract
BACKGROUND: Some evidence in humans suggests that persistent organic pollutants (POPs), including organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs), may alter the blood lipid composition. This study analyzed associations between serum POPs concentrations in young adulthood with blood lipid levels up to 23 years later. METHODS: Serum POPs were measured in year 2 of follow-up (n = 180 men and women, ages: 20-32y), and plasma lipids in follow-up years 2, 7, 10, 15, 20 and 25. 32 POPs were detectable in ≥75% of participants (23 PCBs, 8 OCPs and PBB-153). We created summary scores for PCBs and OCPs for both wet-weight, and lipid standardized (LP) concentrations. We used repeated measures regression adjusting for demographic factors, BMI, smoking, diabetes status, among others. RESULTS: We observed positive associations of the 23 LP-PCB score with total cholesterol (βper SD increase [95%CI]: 5.0 mg/dL [0.7, 9.2]), triglycerides (7.8 mg/dL [-0.9, 16.5]), LDL (4.2 mg/dL [0.2, 8.2]), oxidized LDL 3.4 U/L (-0.05, 6.8), and cholesterol/HDL ratio (0.2 [0.02, 0.3]). The associations for triglycerides (14.7 mg/dL [0.4, 20.1]), cholesterol/HDL (0.33 [0.09, 0.56]) and, to some extent, LDL (4.7 md/dL [-1.6, 10.9]) were only observed among participants in the upper 50th percentile of BMI. Non-dioxin-like PCBs had stronger associations that dioxin-like PCBs. OCPs and PBB-s had positive associations with most outcomes. CONCLUSIONS: PCBs and PBB-153 measured in young adulthood were positively associated with prospective alterations in most blood lipid components, with evidence of effect modification by BMI. Further longitudinal studies with multiple measures of POPs overtime are needed.
BACKGROUND: Some evidence in humans suggests that persistent organic pollutants (POPs), including organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs), may alter the blood lipid composition. This study analyzed associations between serum POPs concentrations in young adulthood with blood lipid levels up to 23 years later. METHODS: Serum POPs were measured in year 2 of follow-up (n = 180 men and women, ages: 20-32y), and plasma lipids in follow-up years 2, 7, 10, 15, 20 and 25. 32 POPs were detectable in ≥75% of participants (23 PCBs, 8 OCPs and PBB-153). We created summary scores for PCBs and OCPs for both wet-weight, and lipid standardized (LP) concentrations. We used repeated measures regression adjusting for demographic factors, BMI, smoking, diabetes status, among others. RESULTS: We observed positive associations of the 23 LP-PCB score with total cholesterol (βper SD increase [95%CI]: 5.0 mg/dL [0.7, 9.2]), triglycerides (7.8 mg/dL [-0.9, 16.5]), LDL (4.2 mg/dL [0.2, 8.2]), oxidized LDL 3.4 U/L (-0.05, 6.8), and cholesterol/HDL ratio (0.2 [0.02, 0.3]). The associations for triglycerides (14.7 mg/dL [0.4, 20.1]), cholesterol/HDL (0.33 [0.09, 0.56]) and, to some extent, LDL (4.7 md/dL [-1.6, 10.9]) were only observed among participants in the upper 50th percentile of BMI. Non-dioxin-like PCBs had stronger associations that dioxin-like PCBs. OCPs and PBB-s had positive associations with most outcomes. CONCLUSIONS:PCBs and PBB-153 measured in young adulthood were positively associated with prospective alterations in most blood lipid components, with evidence of effect modification by BMI. Further longitudinal studies with multiple measures of POPs overtime are needed.
Authors: Miquel Porta; Magda Gasull; José Pumarega; Hannu Kiviranta; Panu Rantakokko; Ole Raaschou-Nielsen; Ingvar A Bergdahl; Torkjel Manning Sandanger; Antoni Agudo; Charlotta Rylander; Therese Haugdahl Nøst; Carolina Donat-Vargas; Dagfinn Aune; Alicia K Heath; Lluís Cirera; Fernando Goñi-Irigoyen; Juan Alguacil; Àlex Giménez-Robert; Anne Tjønneland; Malin Sund; Kim Overvad; Francesca Romana Mancini; Vinciane Rebours; Marie-Christine Boutron-Ruault; Rudolf Kaaks; Matthias B Schulze; Antonia Trichopoulou; Domenico Palli; Sara Grioni; Rosario Tumino; Alessio Naccarati; Salvatore Panico; Roel Vermeulen; J Ramón Quirós; Miguel Rodríguez-Barranco; Sandra M Colorado-Yohar; María-Dolores Chirlaque; Eva Ardanaz; Nick Wareham; Tim Key; Mattias Johansson; Neil Murphy; Pietro Ferrari; Inge Huybrechts; Veronique Chajes; Carlos Alberto Gonzalez; Bas Bueno-de-Mesquita; Marc Gunter; Elisabete Weiderpass; Elio Riboli; Eric J Duell; Verena Katzke; Paolo Vineis Journal: Int J Epidemiol Date: 2022-05-09 Impact factor: 9.685