Fong-Fu Chou1, Jin-Bor Chen2, Shun-Cheng Huang3, Yi-Chai Chan1, Shun-Yu Chi4, Wei-Ting Chen5. 1. Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University, 123, Ta pei Rd, Niao Sung District, Kaohsiung City, Taiwan. 2. Division of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University, 123, Ta pei Rd, Niao Sung District, Kaohsiung City, Taiwan. 3. Department of Pathology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University, 123, Ta pei Rd, Niao Sung District, Kaohsiung City, Taiwan. 4. Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University, 123, Ta pei Rd, Niao Sung District, Kaohsiung City, Taiwan. Electronic address: abraban@cgmh.org.tw. 5. Department of Radiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University, 123, Ta pei Rd, Niao Sung District, Kaohsiung City, Taiwan.
Abstract
BACKGROUND: Changes of calcification scores of the abdominal aorta (CSAA) after total parathyroidectomy plus autotransplantation (TPX + AT) for symptomatic secondary hyperparathyroidism (SSHP) have never been reported. METHODS: Forty-nine patients who successfully underwent TPX + AT for SSHP were enrolled; 13 patients who had regular hemodialysis were enrolled as controls. Preoperatively, patients' age, gender, and duration of dialysis were recorded. Serum Ca, P, alkaline phosphatase (Alk-ptase), intact parathyroid hormone (iPTH), vitamin D, FGF23, and Klotho levels, and CSAA were measured. One year postoperatively, these data were measured again. In the control group, these data were recorded and measured before and one year later. RESULTS: Serum iPTH, Alk-ptase and FGF23 levels and CSAA of the study group were significantly higher than those of the control group. One year postoperatively, serum Ca, P, Alk-ptase, iPTH, and FGF23 levels and CSAA were significantly lower than those before surgery. Except for FGF23 levels, other items of the control group did not change significantly one year later, whereas the study group decreased CSAA more than the control group. CONCLUSION: One year postoperatively, CSAA decreased.
BACKGROUND: Changes of calcification scores of the abdominal aorta (CSAA) after total parathyroidectomy plus autotransplantation (TPX + AT) for symptomatic secondary hyperparathyroidism (SSHP) have never been reported. METHODS: Forty-nine patients who successfully underwent TPX + AT for SSHP were enrolled; 13 patients who had regular hemodialysis were enrolled as controls. Preoperatively, patients' age, gender, and duration of dialysis were recorded. Serum Ca, P, alkaline phosphatase (Alk-ptase), intact parathyroid hormone (iPTH), vitamin D, FGF23, and Klotho levels, and CSAA were measured. One year postoperatively, these data were measured again. In the control group, these data were recorded and measured before and one year later. RESULTS: Serum iPTH, Alk-ptase and FGF23 levels and CSAA of the study group were significantly higher than those of the control group. One year postoperatively, serum Ca, P, Alk-ptase, iPTH, and FGF23 levels and CSAA were significantly lower than those before surgery. Except for FGF23 levels, other items of the control group did not change significantly one year later, whereas the study group decreased CSAA more than the control group. CONCLUSION: One year postoperatively, CSAA decreased.
Authors: Chi Su; Lingqiong Meng; Stanley Z Trooskin; Sue A Shapses; Yuling He; Aseel Al-Dayyeni; Xiangbing Wang Journal: Endocrine Date: 2020-07-24 Impact factor: 3.633