| Literature DB >> 30593874 |
Yuki Mihara1, Makoto Horikawa2, Shumpei Sato2, Fumihiro Eto3, Mitsuru Hanada1, Tomohiro Banno1, Hideyuki Arima1, Hiroki Ushirozako1, Tomohiro Yamada1, Dongmin Xu1, Ayako Okamoto1, Fumiyoshi Yamazaki2, Shiro Takei4, Takao Omura1, Ikuko Yao5, Yukihiro Matsuyama1, Mitsutoshi Setou6.
Abstract
In the current study, we aimed to analyze the lipid changes in the dorsal root ganglion (DRG) after sciatic nerve transection (SNT) using matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI-IMS). We found that the arachidonic acid-containing phosphatidylcholine (AA-PC), PC(16:0/20:4) largely increased, while PC(16:0/18:1), PC(18:0/18:1) and phosphatidic acid (PA)(36:2) levels largely decreased in the DRG following nerve injury. Previous studies show that the increase in PC(16:0/20:4) was associated with neuropathic pain and that decrease in PC(16:0/18:1), PC(18:0/18:1), and PA(36:2) were due to producing lysophosphatidic acid (LPA), an initiator for neuropathic pain. These results suggest that the lipid changes in DRG after SNT could be the result of changes for the cause of neuropathic pain. Thus, blocking of LPA could be potential for treatment of neuropathic pain.Entities:
Keywords: Imaging mass spectrometry; Lysophosphatidic acid; Matrix-assisted laser desorption ionization; Neuropathic pain; Peripheral nerve injury; Sciatic nerve transection
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Year: 2018 PMID： 30593874 DOI： 10.1016/j.neulet.2018.12.035
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046