Elfa Alidrus Idrus1,2, Elina Maria Utti2, Jaakko S Mattila2, Kari Krootila2. 1. Ophthalmology unit, Merauke Government Public Hospital, Merauke, Papua, Indonesia. 2. Ophthalmology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Abstract
PURPOSE: To report our experience with photoactivated chromophore corneal cross-linking (PACK-CXL) for treating keratitis patients. METHODS: This retrospective study consists of 27 eyes of 26 patients with infectious keratitis treated with PACK-CXL at the Helsinki University Hospital between 2009 and 2017. Patients were treated with antibiotics/antifungal medications and underwent PACK-CXL procedure due to lack of clinical response or severe corneal melts. For twenty patients, amniotic membrane transplant (AMT) was done during the same day. Follow-up after cross-linking ranged from 1 week to 12 months. RESULTS: Sixteen infections were related to contact lens wear. Of the 19 eyes showing positive culture, the predominant micro-organism was Pseudomonas aeruginosa (9 cases). The average re-epithelization time was 13 days and in 15 cases (56%) the re-epithelization occurred within one week. In 26 eyes, visual acuity increased and seven patients (26%) had a final visual acuity more or equal to 0.5 (20/40) Snellen. CONCLUSIONS: PACK-CXL seems to be a safe and potential option for treating patient with infectious keratitis who do not respond to antibiotic therapy.
PURPOSE: To report our experience with photoactivated chromophore corneal cross-linking (PACK-CXL) for treating keratitispatients. METHODS: This retrospective study consists of 27 eyes of 26 patients with infectious keratitis treated with PACK-CXL at the Helsinki University Hospital between 2009 and 2017. Patients were treated with antibiotics/antifungal medications and underwent PACK-CXL procedure due to lack of clinical response or severe corneal melts. For twenty patients, amniotic membrane transplant (AMT) was done during the same day. Follow-up after cross-linking ranged from 1 week to 12 months. RESULTS: Sixteen infections were related to contact lens wear. Of the 19 eyes showing positive culture, the predominant micro-organism was Pseudomonas aeruginosa (9 cases). The average re-epithelization time was 13 days and in 15 cases (56%) the re-epithelization occurred within one week. In 26 eyes, visual acuity increased and seven patients (26%) had a final visual acuity more or equal to 0.5 (20/40) Snellen. CONCLUSIONS: PACK-CXL seems to be a safe and potential option for treating patient with infectious keratitis who do not respond to antibiotic therapy.
Authors: Jurriaan Brekelmans; Judith Veugen; Koen Rieff; Mor M Dickman; Alexa Goz; Petra Wolffs; Alexander Brandis; Tos T J M Berendschot; Rudy M M A Nuijts; Avigdor Scherz; Arie L Marcovich Journal: Transl Vis Sci Technol Date: 2020-09-03 Impact factor: 3.283