Literature DB >> 30593530

Structure of a transporter domain emerges.

Chris Ulens1.   

Abstract

Magnesium homeostasis relies on transporters like the CNNM family, but little information on these proteins' structure and regulation limits our understanding of their biology and functions in disease. New characterization of a conserved cytoplasmic domain now confirms the presence of a self-liganded architecture that is indispensable for Mg2+ efflux and suggests a possible role for a dimeric assembly.
© 2018 Ulens.

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Year:  2018        PMID： 30593530      PMCID： PMC6311507          DOI： 10.1074/jbc.H118.006869

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  10 in total

1.  Structures of the Human HCN1 Hyperpolarization-Activated Channel.

Authors:  Chia-Hsueh Lee; Roderick MacKinnon
Journal:  Cell       Date:  2017-01-12       Impact factor: 41.582

2.  Structure of a eukaryotic cyclic-nucleotide-gated channel.

Authors:  Minghui Li; Xiaoyuan Zhou; Shu Wang; Ioannis Michailidis; Ye Gong; Deyuan Su; Huan Li; Xueming Li; Jian Yang
Journal:  Nature       Date:  2017-01-18       Impact factor: 49.962

3.  Structure of the cyclic-AMP-responsive exchange factor Epac2 in its auto-inhibited state.

Authors:  Holger Rehmann; Joost Das; Puck Knipscheer; Alfred Wittinghofer; Johannes L Bos
Journal:  Nature       Date:  2006-02-02       Impact factor: 49.962

4.  Cryo-EM Structure of the Open Human Ether-à-go-go-Related K+ Channel hERG.

Authors:  Weiwei Wang; Roderick MacKinnon
Journal:  Cell       Date:  2017-04-20       Impact factor: 41.582

5.  Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase.

Authors:  D R Knighton; J H Zheng; L F Ten Eyck; V A Ashford; N H Xuong; S S Taylor; J M Sowadski
Journal:  Science       Date:  1991-07-26       Impact factor: 47.728

6.  The cyclic nucleotide-binding homology domain of the integral membrane protein CNNM mediates dimerization and is required for Mg2+ efflux activity.

Authors:  Yu Seby Chen; Guennadi Kozlov; Rayan Fakih; Yosuke Funato; Hiroaki Miki; Kalle Gehring
Journal:  J Biol Chem       Date:  2018-10-19       Impact factor: 5.157

7.  Structure of catabolite gene activator protein at 2.9 A resolution suggests binding to left-handed B-DNA.

Authors:  D B McKay; T A Steitz
Journal:  Nature       Date:  1981-04-30       Impact factor: 49.962

8.  Structure of the voltage-gated K⁺ channel Eag1 reveals an alternative voltage sensing mechanism.

Authors:  Jonathan R Whicher; Roderick MacKinnon
Journal:  Science       Date:  2016-08-12       Impact factor: 47.728

9.  Structure of the carboxy-terminal region of a KCNH channel.

Authors:  Tinatin I Brelidze; Anne E Carlson; Banumathi Sankaran; William N Zagotta
Journal:  Nature       Date:  2012-01-09       Impact factor: 49.962

10.  Mutations in CNNM4 cause Jalili syndrome, consisting of autosomal-recessive cone-rod dystrophy and amelogenesis imperfecta.

Authors:  David A Parry; Alan J Mighell; Walid El-Sayed; Roger C Shore; Ismail K Jalili; Hélène Dollfus; Agnes Bloch-Zupan; Roman Carlos; Ian M Carr; Louise M Downey; Katharine M Blain; David C Mansfield; Mehdi Shahrabi; Mansour Heidari; Parissa Aref; Mohsen Abbasi; Michel Michaelides; Anthony T Moore; Jennifer Kirkham; Chris F Inglehearn
Journal:  Am J Hum Genet       Date:  2009-02-05       Impact factor: 11.025
  10 in total

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