Literature DB >> 30591716

The implications of target saturation for the use of drug-target residence time.

Wilhelmus E A de Witte1, Meindert Danhof1, Piet H van der Graaf1,2, Elizabeth C M de Lange1.   

Abstract

Mesh：

Substances：

Year:  2018        PMID： 30591716     DOI： 10.1038/nrd.2018.234

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN： 1474-1776            Impact factor:   84.694


× No keyword cloud information.
  9 in total

Review 1.  Slow antagonist dissociation and long-lasting in vivo receptor protection.

Authors:  Georges Vauquelin; Isabelle Van Liefde
Journal:  Trends Pharmacol Sci       Date:  2006-07       Impact factor: 14.819

Review 2.  Drug-target residence time and its implications for lead optimization.

Authors:  Robert A Copeland; David L Pompliano; Thomas D Meek
Journal:  Nat Rev Drug Discov       Date:  2006-08-04       Impact factor: 84.694

3.  Drug target residence time: a misleading concept.

Authors:  Rutger H A Folmer
Journal:  Drug Discov Today       Date:  2017-08-03       Impact factor: 7.851

Review 4.  Pharmacokinetics and the drug-target residence time concept.

Authors:  Göran Dahl; Tomas Akerud
Journal:  Drug Discov Today       Date:  2013-03-14       Impact factor: 7.851

Review 5.  In vivo Target Residence Time and Kinetic Selectivity: The Association Rate Constant as Determinant.

Authors:  Wilhelmus E A de Witte; Meindert Danhof; Piet H van der Graaf; Elizabeth C M de Lange
Journal:  Trends Pharmacol Sci       Date:  2016-07-06       Impact factor: 14.819

6.  Kinetics of pharmacologic effects.

Authors:  G Levy
Journal:  Clin Pharmacol Ther       Date:  1966 May-Jun       Impact factor: 6.875

7.  Neurokinin 1 receptor antagonists: correlation between in vitro receptor interaction and in vivo efficacy.

Authors:  Erik Lindström; Bengt von Mentzer; Ingrid Påhlman; Ingela Ahlstedt; Anna Uvebrant; Elin Kristensson; Rakel Martinsson; Anna Novén; Jennie de Verdier; Georges Vauquelin
Journal:  J Pharmacol Exp Ther       Date:  2007-06-15       Impact factor: 4.030

8.  Drug-Target Kinetics in Drug Discovery.

Authors:  Peter J Tonge
Journal:  ACS Chem Neurosci       Date:  2017-07-14       Impact factor: 4.418

9.  A novel CCR2 antagonist inhibits atherogenesis in apoE deficient mice by achieving high receptor occupancy.

Authors:  Ilze Bot; Natalia V Ortiz Zacarías; Wilhelmus E A de Witte; Henk de Vries; Peter J van Santbrink; Daniël van der Velden; Mara J Kröner; Dirk-Jan van der Berg; Dean Stamos; Elizabeth C M de Lange; Johan Kuiper; Adriaan P IJzerman; Laura H Heitman
Journal:  Sci Rep       Date:  2017-03-03       Impact factor: 4.379
  9 in total
  3 in total

Review 1.  Enhanced-Sampling Simulations for the Estimation of Ligand Binding Kinetics: Current Status and Perspective.

Authors:  Katya Ahmad; Andrea Rizzi; Riccardo Capelli; Davide Mandelli; Wenping Lyu; Paolo Carloni
Journal:  Front Mol Biosci       Date:  2022-06-08

Review 2.  Bioresponsive Polymers for Nanomedicine-Expectations and Reality!

Authors:  Sabina Quader; Joachim F R Van Guyse
Journal:  Polymers (Basel)       Date:  2022-09-03       Impact factor: 4.967

3.  Structure-Based Design of A-1293102, a Potent and Selective BCL-XL Inhibitor.

Authors:  Zhi-Fu Tao; Xilu Wang; Jun Chen; Justin P Ingram; Sha Jin; Russell A Judge; Peter J Kovar; Chang Park; Chaohong Sun; Brian D Wakefield; Li Zhou; Haichao Zhang; Steven W Elmore; Darren C Phillips; Andrew S Judd; Joel D Leverson; Andrew J Souers
Journal:  ACS Med Chem Lett       Date:  2021-05-12       Impact factor: 4.632
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.