Dongwei Zhang1,2, William D Williams3, Jinping Lai4. 1. Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, U.S.A. 2. Department of Pathology, Immunology and Laboratory of Medicine, University of Florida College of Medicine, Gainesville, FL, U.S.A. 3. Department of Pathology and Laboratory Medicine, Broward Health North, Deerfield Beach, FL, U.S.A. 4. Department of Pathology, Immunology and Laboratory of Medicine, University of Florida College of Medicine, Gainesville, FL, U.S.A. jinpinglai@ufl.edu.
Abstract
BACKGROUND: Colonic mesenteric dedifferentiated liposarcoma is a rare entity. CASE REPORT: A 65-year-old male developed a 6 cm diameter right-side intra-abdominal mesenteric mass. A biopsy of the mass was performed and the pathology diagnosis was a spindle cell neoplasm most consistent with low-grade sarcoma. The mass was found to involve the ileocolic vessels in the mesentery on the right side of the abdomen, and therefore the patient received right hemicolectomy with mesenteric mass resection. Pathology confirmed a dedifferentiated liposarcoma (DDLPS) arising in a well-differentiated liposarcoma/atypical lipomatous tumor with myxoid changes. The tumor cells were positive for MDM2 amplification by fluorescence in situ hybridization. After 6 months of follow-up, our patient showed no sign of recurrence. CONCLUSION: We report an unusual cecal mesenteric DDLPS which was successfully resected by right hemicolectomy. The results suggest that DDLPS should be considered in the differential diagnosis of patients presenting with a spindle cell neoplasm in the mesentery. Copyright
BACKGROUND: Colonic mesenteric dedifferentiated liposarcoma is a rare entity. CASE REPORT: A 65-year-old male developed a 6 cm diameter right-side intra-abdominal mesenteric mass. A biopsy of the mass was performed and the pathology diagnosis was a spindle cell neoplasm most consistent with low-grade sarcoma. The mass was found to involve the ileocolic vessels in the mesentery on the right side of the abdomen, and therefore the patient received right hemicolectomy with mesenteric mass resection. Pathology confirmed a dedifferentiated liposarcoma (DDLPS) arising in a well-differentiated liposarcoma/atypical lipomatous tumor with myxoid changes. The tumor cells were positive for MDM2 amplification by fluorescence in situ hybridization. After 6 months of follow-up, our patient showed no sign of recurrence. CONCLUSION: We report an unusual cecal mesenteric DDLPS which was successfully resected by right hemicolectomy. The results suggest that DDLPS should be considered in the differential diagnosis of patients presenting with a spindle cell neoplasm in the mesentery. Copyright
Authors: Elia Guadagno; Roberto Peltrini; Loredana Stasio; Francesco Fiorentino; Luigi Bucci; Luigi Terracciano; Luigi Insabato Journal: Int J Colorectal Dis Date: 2019-09-09 Impact factor: 2.571