Avalon Ernstson1, Katrin Christine Asciutto2, Johan Sturesson2, Jonas Norén2, Ola Forslund3, Christer Borgfeldt2. 1. Department of Obstetrics and Gynecology, Skåne University Hospital, Lund University, Lund, Sweden avalon.ernstson@med.lu.se. 2. Department of Obstetrics and Gynecology, Skåne University Hospital, Lund University, Lund, Sweden. 3. Department of Medical Microbiology, Laboratory Medicine Region Skåne, Lund University, Lund, Sweden.
Abstract
BACKGROUND/AIM: Cervical cancer is associated with poorer diagnosis among the elderly and pap-smear screening has a lower sensitivity. Self-sampling for detection of high-risk human papillomavirus (hr-HPV) may be an alternative screening method. The aim of this study was to analyze the response rate to vaginal HPV self-sampling and the HPV mRNA prevalence among women 69-70 years. MATERIALS AND METHODS: An HPV self-sampling kit was sent to 1,000 women 69-70 years whom had not taken a cervical smear in ≥5 years. The samples were analyzed by the Aptima HPV mRNA assay. HPV-positive women were recalled for a follow-up examination. RESULTS: The self-sample response rate was 43.3%. The HPV mRNA prevalence was 6.2%. All HPV-positive women attended follow-up. CONCLUSION: HPV self-sampling was accepted among older women. Although the HPV mRNA prevalence was 6.2%, no high-grade cytological abnormalities were found. Larger studies are needed to elucidate hr-HPV self-sampling as a tool to identify older women at risk of cervical cancer. Copyright
BACKGROUND/AIM: Cervical cancer is associated with poorer diagnosis among the elderly and pap-smear screening has a lower sensitivity. Self-sampling for detection of high-risk human papillomavirus (hr-HPV) may be an alternative screening method. The aim of this study was to analyze the response rate to vaginal HPV self-sampling and the HPV mRNA prevalence among women 69-70 years. MATERIALS AND METHODS: An HPV self-sampling kit was sent to 1,000 women 69-70 years whom had not taken a cervical smear in ≥5 years. The samples were analyzed by the Aptima HPV mRNA assay. HPV-positive women were recalled for a follow-up examination. RESULTS: The self-sample response rate was 43.3%. The HPV mRNA prevalence was 6.2%. All HPV-positive women attended follow-up. CONCLUSION: HPV self-sampling was accepted among older women. Although the HPV mRNA prevalence was 6.2%, no high-grade cytological abnormalities were found. Larger studies are needed to elucidate hr-HPV self-sampling as a tool to identify older women at risk of cervical cancer. Copyright
Authors: Joanna Świderska-Kiec; Krzysztof Czajkowski; Julia Zaręba-Szczudlik; Joanna Kacperczyk-Bartnik; Paweł Bartnik; Ewa Romejko-Wolniewicz Journal: In Vivo Date: 2020 May-Jun Impact factor: 2.155
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