Yu-Tsun Su1, Yen-Ting Lin2, Ching-Chi Yang3, Shang-Shyue Tsai4, Jiu-Yao Wang5, Ya-Ling Huang6, Ting-I Lin7, Tsun-Mei Lin8, Yu-Cheng Tsai9, Hong-Ren Yu10, Ching-Chung Tsai11, Ming-Chun Yang12. 1. Division of Pediatric Allergy, Immunology, and Pulmonology, Department of Pediatrics, E-Da Hospital/I-Shou University, Kaohsiung, Taiwan; School of Medicine for International Students, I-Shou University, Kaohsiung, Taiwan; School of Chinese Medicine for Post Baccalaureate, I-Shou University, Kaohsiung, Taiwan. 2. Division of Pediatric Infectious Disease, Department of Pediatrics, E-Da Hospital/I-Shou University, Kaohsiung, Taiwan; Asanga International Aid, Kaohsiung, Taiwan. 3. Division of Pediatric Infectious Disease, Department of Pediatrics, E-Da Hospital/I-Shou University, Kaohsiung, Taiwan; Love Child Clinic, Hsinchu County, Taiwan. 4. Department of Healthcare Administration, I-Shou University, Kaohsiung, Taiwan. 5. The Institute of Basic Medical Sciences, National Cheng Kung University, Tainan, Taiwan; Department of Pediatrics, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address: a122@mail.ncku.edu.tw. 6. The Institute of Basic Medical Sciences, National Cheng Kung University, Tainan, Taiwan; Department of Laboratory Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan. Electronic address: ed105471@gmail.com. 7. Division of Pediatric Allergy, Immunology, and Pulmonology, Department of Pediatrics, E-Da Hospital/I-Shou University, Kaohsiung, Taiwan; Division of Pediatric Infectious Disease, Department of Pediatrics, E-Da Hospital/I-Shou University, Kaohsiung, Taiwan. 8. Department of Laboratory Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan; Medical Research, E-Da Hospital/I-Shou University, Kaohsiung, Taiwan; Department of Medical Laboratory Science, I-Shou University, Kaohsiung, Taiwan. 9. Division of Pediatric Allergy, Immunology, and Pulmonology, Department of Pediatrics, E-Da Hospital/I-Shou University, Kaohsiung, Taiwan. 10. Department of Pediatrics, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Taiwan; Graduate Institute of Clinical Medical Science, Chang Gung University College of Medicine, Taiwan. 11. School of Chinese Medicine for Post Baccalaureate, I-Shou University, Kaohsiung, Taiwan; Department of Pediatrics, E-Da Hospital/I-Shou University, Kaohsiung, Taiwan. 12. School of Medicine for International Students, I-Shou University, Kaohsiung, Taiwan; School of Chinese Medicine for Post Baccalaureate, I-Shou University, Kaohsiung, Taiwan; Department of Pediatrics, E-Da Hospital/I-Shou University, Kaohsiung, Taiwan.
Abstract
BACKGROUND/PURPOSES: Human rhinovirus type C (HRV-C) has been associated with asthma exacerbation (AE) in children in several countries. However, in Taiwan the association between HRV, especially HRV-C, and AE in children has yet to be elucidated. We sought to investigate the prevalence of respiratory viruses in children with acute lower respiratory tract infection (ALRTI) in Taiwan and the association between different types of HRV and AE in children. METHODS: This prospective study was conducted from 2011 to 2013, and enrolled children with ALRTI, including an asthma exacerbation group (AE; n = 28) and a Non-asthma group (n = 66). Viruses were detected by culture, reverse transcription-polymerase chain reaction, and molecular sequencing of nasopharyngeal swabs. RESULTS: The prevalence of identified respiratory viruses was 78.6% in the AE group and 65.2% in the Non-asthma group. The prevalence rates of HRV and HRV-C were significantly higher in the AE group than in the Non-asthma group (67.9% vs. 33.3% in HRV, p = 0.002; and 50% vs. 15.2% in HRV-C, p < 0.001). Among the children with HRV, the prevalence of HRV-C (68.4%) was higher than that of the other types of HRV (31.6%, including HRV-A 26.3%, and HRV-B 5.3%) in the AE group but not in the Non-asthma group (40.9% vs. 59.1%). CONCLUSIONS: HRV is the most predominant viral infection responsible for pediatric AE in Taiwan, and HRV-C is responsible for more of these exacerbations than HRV-A or HRV-B.
BACKGROUND/PURPOSES: Human rhinovirus type C (HRV-C) has been associated with asthma exacerbation (AE) in children in several countries. However, in Taiwan the association between HRV, especially HRV-C, and AE in children has yet to be elucidated. We sought to investigate the prevalence of respiratory viruses in children with acute lower respiratory tract infection (ALRTI) in Taiwan and the association between different types of HRV and AE in children. METHODS: This prospective study was conducted from 2011 to 2013, and enrolled children with ALRTI, including an asthma exacerbation group (AE; n = 28) and a Non-asthma group (n = 66). Viruses were detected by culture, reverse transcription-polymerase chain reaction, and molecular sequencing of nasopharyngeal swabs. RESULTS: The prevalence of identified respiratory viruses was 78.6% in the AE group and 65.2% in the Non-asthma group. The prevalence rates of HRV and HRV-C were significantly higher in the AE group than in the Non-asthma group (67.9% vs. 33.3% in HRV, p = 0.002; and 50% vs. 15.2% in HRV-C, p < 0.001). Among the children with HRV, the prevalence of HRV-C (68.4%) was higher than that of the other types of HRV (31.6%, including HRV-A 26.3%, and HRV-B 5.3%) in the AE group but not in the Non-asthma group (40.9% vs. 59.1%). CONCLUSIONS: HRV is the most predominant viral infection responsible for pediatric AE in Taiwan, and HRV-C is responsible for more of these exacerbations than HRV-A or HRV-B.
Authors: Yingyuan Sun; Kelly Watters; Marchel G Hill; Qianglin Fang; Yue Liu; Richard J Kuhn; Thomas Klose; Michael G Rossmann; Ann C Palmenberg Journal: Proc Natl Acad Sci U S A Date: 2020-03-09 Impact factor: 11.205
Authors: Erwan Sallard; Katarzyna Niespodziana; Maja Bajic; Thomas Schlederer; Peter Errhalt; Ann-Kathrin Behrendt; Stefan Wirth; Almut Meyer-Bahlburg; Anja Ehrhardt; Rudolf Valenta; Malik Aydin Journal: Viruses Date: 2022-08-24 Impact factor: 5.818