Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Antibody-Mediated Virus Neutralization Is Not a Universal Mechanism of Marburg, Ebola, or Sosuga Virus Clearance in Egyptian Rousette Bats.

Literature DB >> 30590775

Antibody-Mediated Virus Neutralization Is Not a Universal Mechanism of Marburg, Ebola, or Sosuga Virus Clearance in Egyptian Rousette Bats.

Amy J Schuh^1,2, Brian R Amman¹, Tara K Sealy¹, Markus H Kainulainen¹, Ayan K Chakrabarti¹, Lisa W Guerrero¹, Stuart T Nichol¹, Cesar G Albarino¹, Jonathan S Towner^1,3.

Abstract

Although bats are increasingly being recognized as natural reservoir hosts of emerging zoonotic viruses, little is known about how they control and clear virus infection in the absence of clinical disease. Here, we test >50 convalescent sera from Egyptian rousette bats (ERBs) experimentally primed or prime-boosted with Marburg virus, Ebola virus, or Sosuga virus for the presence of virus-specific neutralizing antibodies, using infectious reporter viruses. After serum neutralization testing, we conclude that antibody-mediated virus neutralization does not contribute significantly to the control and clearance of Marburg virus, Ebola virus, or Sosuga virus infection in ERBs. Published by Oxford University Press for the Infectious Diseases Society of America 2018.

Entities: CellLine Chemical Disease Species

Keywords: Ebola virus; Marburg virus; Neutralization; Sosuga virus; bats

Mesh：

Substances：
Antibodies, Viral

Year: 2019 PMID： 30590775 PMCID： PMC6519049 DOI： 10.1093/infdis/jiy733

Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226

12 in total

1. Mechanism of human antibody-mediated neutralization of Marburg virus.

Authors: Andrew I Flyak; Philipp A Ilinykh; Charles D Murin; Tania Garron; Xiaoli Shen; Marnie L Fusco; Takao Hashiguchi; Zachary A Bornholdt; James C Slaughter; Gopal Sapparapu; Curtis Klages; Thomas G Ksiazek; Andrew B Ward; Erica Ollmann Saphire; Alexander Bukreyev; James E Crowe
Journal: Cell Date: 2015-02-26 Impact factor: 41.582

2. Development of a reverse genetics system to generate a recombinant Ebola virus Makona expressing a green fluorescent protein.

Authors: César G Albariño; Lisa Wiggleton Guerrero; Michael K Lo; Stuart T Nichol; Jonathan S Towner
Journal: Virology Date: 2015-06-27 Impact factor: 3.616

3. A Recently Discovered Pathogenic Paramyxovirus, Sosuga Virus, is Present in Rousettus aegyptiacus Fruit Bats at Multiple Locations in Uganda.

Authors: Brian R Amman; Cesar G Albariño; Brian H Bird; Luke Nyakarahuka; Tara K Sealy; Stephen Balinandi; Amy J Schuh; Shelly M Campbell; Ute Ströher; Megan E B Jones; Megan E Vodzack; DeeAnn M Reeder; Winyi Kaboyo; Stuart T Nichol; Jonathan S Towner
Journal: J Wildl Dis Date: 2015-04-28 Impact factor: 1.535

4. Virological and serological findings in Rousettus aegyptiacus experimentally inoculated with vero cells-adapted hogan strain of Marburg virus.

Authors: Janusz T Paweska; Petrus Jansen van Vuren; Justin Masumu; Patricia A Leman; Antoinette A Grobbelaar; Monica Birkhead; Sarah Clift; Robert Swanepoel; Alan Kemp
Journal: PLoS One Date: 2012-09-17 Impact factor: 3.240

5. Seasonal pulses of Marburg virus circulation in juvenile Rousettus aegyptiacus bats coincide with periods of increased risk of human infection.

Authors: Brian R Amman; Serena A Carroll; Zachary D Reed; Tara K Sealy; Stephen Balinandi; Robert Swanepoel; Alan Kemp; Bobbie Rae Erickson; James A Comer; Shelley Campbell; Deborah L Cannon; Marina L Khristova; Patrick Atimnedi; Christopher D Paddock; Rebekah J Kent Crockett; Timothy D Flietstra; Kelly L Warfield; Robert Unfer; Edward Katongole-Mbidde; Robert Downing; Jordan W Tappero; Sherif R Zaki; Pierre E Rollin; Thomas G Ksiazek; Stuart T Nichol; Jonathan S Towner
Journal: PLoS Pathog Date: 2012-10-04 Impact factor: 6.823

6. Experimental Inoculation of Egyptian Rousette Bats (Rousettus aegyptiacus) with Viruses of the Ebolavirus and Marburgvirus Genera.

Authors: Megan E B Jones; Amy J Schuh; Brian R Amman; Tara K Sealy; Sherif R Zaki; Stuart T Nichol; Jonathan S Towner
Journal: Viruses Date: 2015-06-25 Impact factor: 5.048

7. Egyptian rousette bats maintain long-term protective immunity against Marburg virus infection despite diminished antibody levels.

Authors: Amy J Schuh; Brian R Amman; Tara K Sealy; Jessica R Spengler; Stuart T Nichol; Jonathan S Towner
Journal: Sci Rep Date: 2017-08-18 Impact factor: 4.379

8. Modelling filovirus maintenance in nature by experimental transmission of Marburg virus between Egyptian rousette bats.

Authors: Amy J Schuh; Brian R Amman; Megan E B Jones; Tara K Sealy; Luke S Uebelhoer; Jessica R Spengler; Brock E Martin; Jo Ann D Coleman-McCray; Stuart T Nichol; Jonathan S Towner
Journal: Nat Commun Date: 2017-02-13 Impact factor: 14.919

9. The Egyptian Rousette Genome Reveals Unexpected Features of Bat Antiviral Immunity.

Authors: Stephanie S Pavlovich; Sean P Lovett; Galina Koroleva; Jonathan C Guito; Catherine E Arnold; Elyse R Nagle; Kirsten Kulcsar; Albert Lee; Françoise Thibaud-Nissen; Adam J Hume; Elke Mühlberger; Luke S Uebelhoer; Jonathan S Towner; Raul Rabadan; Mariano Sanchez-Lockhart; Thomas B Kepler; Gustavo Palacios
Journal: Cell Date: 2018-04-26 Impact factor: 66.850

10. Experimental Inoculation of Egyptian Fruit Bats (Rousettus aegyptiacus) with Ebola Virus.

Authors: Janusz T Paweska; Nadia Storm; Antoinette A Grobbelaar; Wanda Markotter; Alan Kemp; Petrus Jansen van Vuren
Journal: Viruses Date: 2016-01-22 Impact factor: 5.048

8 in total

1. Zaire ebolavirus surveillance near the Bikoro region of the Democratic Republic of the Congo during the 2018 outbreak reveals presence of seropositive bats.

Authors: Stephanie N Seifert; Robert J Fischer; Eeva Kuisma; Cynthia Badzi Nkoua; Gerard Bounga; Marc-Joël Akongo; Jonathan E Schulz; Beatriz Escudero-Pérez; Beal-Junior Akoundzie; Vishnou Reize Bani Ampiri; Ankara Dieudonne; Ghislain Dzeret Indolo; Serge D Kaba; Igor Louzolo; Lucette Nathalie Macosso; Yanne Mavoungou; Valchy Bel-Bebi Miegakanda; Rock Aimé Nina; Kevin Tolovou Samabide; Alain I Ondzie; Francine Ntoumi; César Muñoz-Fontela; Jean-Vivien Mombouli; Sarah H Olson; Chris Walzer; Fabien Roch Niama; Vincent J Munster
Journal: PLoS Negl Trop Dis Date: 2022-06-22

Review 2. Molecular, ecological, and behavioral drivers of the bat-virus relationship.

Authors: Victoria Gonzalez; Arinjay Banerjee
Journal: iScience Date: 2022-07-20

3. Histopathologic and Immunohistochemical Evaluation of Induced Lesions, Tissue Tropism and Host Responses following Experimental Infection of Egyptian Rousette Bats (Rousettus aegyptiacus) with the Zoonotic Paramyxovirus, Sosuga Virus.

Authors: Shannon G M Kirejczyk; Brian R Amman; Amy J Schuh; Tara K Sealy; César G Albariño; Jian Zhang; Corrie C Brown; Jonathan S Towner
Journal: Viruses Date: 2022-06-12 Impact factor: 5.818

4. What is stirring in the reservoir? Modelling mechanisms of henipavirus circulation in fruit bat hosts.

Authors: Emma E Glennon; Daniel J Becker; Alison J Peel; Romain Garnier; Richard D Suu-Ire; Louise Gibson; David T S Hayman; James L N Wood; Andrew A Cunningham; Raina K Plowright; Olivier Restif
Journal: Philos Trans R Soc Lond B Biol Sci Date: 2019-08-12 Impact factor: 6.237

Review 8. Coronavirus, the King Who Wanted More Than a Crown: From Common to the Highly Pathogenic SARS-CoV-2, Is the Key in the Accessory Genes?

Authors: Nathalie Chazal
Journal: Front Microbiol Date: 2021-07-14 Impact factor: 5.640