Fred K Tabung1,2, Katharina Nimptsch2,3, Edward L Giovannucci2,4,5,6. 1. Division of Medical Oncology, Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, OH. 2. Departments of Nutrition. 3. Molecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine, Berlin, Germany. 4. Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA. 5. Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA. 6. Department of Medicine, Harvard Medical School, Boston, MA.
Abstract
BACKGROUND: The dietary insulin index (II) directly quantifies dietary effects on postprandial insulin secretion, whereas the empirical dietary index for hyperinsulinemia (EDIH), based on fasting C-peptide concentrations, is primarily reflective of insulin resistance. How these scores are related to nonfasting C-peptide in cohort studies has not been examined. OBJECTIVE: We investigated the extent to which EDIH and II scores predict plasma C-peptide concentrations, in cross-sectional analyses by postprandial duration at blood collection from 1 to ≥15 h. METHODS: Both EDIH and II scores were calculated from food-frequency questionnaire data reported by 3964 men in the Health Professionals Follow-up Study (1993-1995) and 6215 women in the Nurses' Health Study (1989-1990) who were not diabetic. We constructed 12 multivariable-adjusted linear regression models separately in men and women, by postprandial duration, to calculate relative differences and absolute values of plasma C-peptide concentrations in dietary index quintiles. RESULTS: In both men and women, C-peptide concentrations were elevated 1-2 h after eating and declined with increasing postprandial duration. In men, percent differences in C-peptide concentration in the highest compared with lowest dietary index quintile were: EDIH: 0-1 h: 50%; 2 h: 22%; 14 h: 14%; ≥15 h: 30% (all P-trend< 0.05). II: 0-1 h: 19% (P-trend = 0.09); 2 h: 3% (P-trend = 0.09); 14 h: -6% (P-trend = 0.17); ≥15 h: -15% (P-trend = 0.02). Corresponding results among women were: EDIH: 0-1 h: 29% (P-trend = 0.002); 2 h: 33% (P-trend = 0.009); 14 h: 44% (P-trend < 0.0001); ≥15 h: 40% (P-trend < 0.0001). II: 0-1 h: -12% (P-trend = 0.09); 2 h: 17% (P-trend = 0.09); 14 h: -14% (P-trend = 0.009); ≥15 h: -3% (P-trend = 0.37). CONCLUSION: The EDIH was superior to the II in predicting both fasting and nonfasting C-peptide concentrations, suggesting that the EDIH may be better in assessing dietary effects of hyperinsulinemia on disease risk in adult men and women.
BACKGROUND: The dietary insulin index (II) directly quantifies dietary effects on postprandial insulin secretion, whereas the empirical dietary index for hyperinsulinemia (EDIH), based on fasting C-peptide concentrations, is primarily reflective of insulin resistance. How these scores are related to nonfasting C-peptide in cohort studies has not been examined. OBJECTIVE: We investigated the extent to which EDIH and II scores predict plasma C-peptide concentrations, in cross-sectional analyses by postprandial duration at blood collection from 1 to ≥15 h. METHODS: Both EDIH and II scores were calculated from food-frequency questionnaire data reported by 3964 men in the Health Professionals Follow-up Study (1993-1995) and 6215 women in the Nurses' Health Study (1989-1990) who were not diabetic. We constructed 12 multivariable-adjusted linear regression models separately in men and women, by postprandial duration, to calculate relative differences and absolute values of plasma C-peptide concentrations in dietary index quintiles. RESULTS: In both men and women, C-peptide concentrations were elevated 1-2 h after eating and declined with increasing postprandial duration. In men, percent differences in C-peptide concentration in the highest compared with lowest dietary index quintile were: EDIH: 0-1 h: 50%; 2 h: 22%; 14 h: 14%; ≥15 h: 30% (all P-trend< 0.05). II: 0-1 h: 19% (P-trend = 0.09); 2 h: 3% (P-trend = 0.09); 14 h: -6% (P-trend = 0.17); ≥15 h: -15% (P-trend = 0.02). Corresponding results among women were: EDIH: 0-1 h: 29% (P-trend = 0.002); 2 h: 33% (P-trend = 0.009); 14 h: 44% (P-trend < 0.0001); ≥15 h: 40% (P-trend < 0.0001). II: 0-1 h: -12% (P-trend = 0.09); 2 h: 17% (P-trend = 0.09); 14 h: -14% (P-trend = 0.009); ≥15 h: -3% (P-trend = 0.37). CONCLUSION: The EDIH was superior to the II in predicting both fasting and nonfasting C-peptide concentrations, suggesting that the EDIH may be better in assessing dietary effects of hyperinsulinemia on disease risk in adult men and women.
Authors: Weike Wang; Teresa T Fung; Molin Wang; Stephanie A Smith-Warner; Edward L Giovannucci; Fred K Tabung Journal: JNCI Cancer Spectr Date: 2019-01-30
Authors: Dong Hoon Lee; Jun Li; Yanping Li; Gang Liu; Kana Wu; Shilpa Bhupathiraju; Eric B Rimm; Kathryn M Rexrode; JoAnn E Manson; Walter C Willett; Frank B Hu; Fred K Tabung; Edward L Giovannucci Journal: Diabetes Care Date: 2020-09-01 Impact factor: 19.112
Authors: Ni Shi; Susan Olivo-Marston; Qi Jin; Desmond Aroke; Joshua J Joseph; Steven K Clinton; JoAnn E Manson; Kathryn M Rexrode; Yasmin Mossavar-Rahmani; Lesley Fels Tinker; Aladdin H Shadyab; Rhonda S Arthur; Linda G Snetselaar; Linda Van Horn; Fred K Tabung Journal: J Acad Nutr Diet Date: 2021-04-13 Impact factor: 5.234
Authors: Wanshui Yang; Jing Sui; Longgang Zhao; Yanan Ma; Fred K Tabung; Tracey G Simon; Dong Hoon Lee; Xufen Zeng; Long H Nguyen; Jeffrey A Meyerhardt; Andrew T Chan; Edward L Giovannucci; Xuehong Zhang Journal: Cancer Epidemiol Biomarkers Prev Date: 2021-01-29 Impact factor: 4.090
Authors: Yang Hu; Xuehong Zhang; Yanan Ma; Chen Yuan; Molin Wang; Kana Wu; Fred K Tabung; Deirdre Tobias; Frank B Hu; Edward Giovannucci; Mingyang Song Journal: J Natl Cancer Inst Date: 2021-04-06 Impact factor: 11.816
Authors: Fred K Tabung; Raji Balasubramanian; Liming Liang; Steven K Clinton; Elizabeth M Cespedes Feliciano; JoAnn E Manson; Linda Van Horn; Jean Wactawski-Wende; Clary B Clish; Edward L Giovannucci; Kathryn M Rexrode Journal: Metabolites Date: 2019-06-24
Authors: Yin Zhang; Mingyang Song; Andrew T Chan; Eva S Schernhammer; Brian M Wolpin; Meir J Stampfer; Jeffrey A Meyerhardt; Charles S Fuchs; Susan B Roberts; Walter C Willett; Frank B Hu; Edward L Giovannucci; Kimmie Ng Journal: Am J Clin Nutr Date: 2021-11-08 Impact factor: 8.472
Authors: Fred K Tabung; Anne Noonan; Dong Hoon Lee; Mingyang Song; Steven K Clinton; Daniel Spakowicz; Kana Wu; En Cheng; Jeffrey A Meyerhardt; Charles S Fuchs; Edward L Giovannucci Journal: BMC Cancer Date: 2020-08-27 Impact factor: 4.430