| Literature DB >> 30590560 |
Benjamin C Haller1, Philipp W Messer1.
Abstract
The SLiM forward genetic simulation framework has proved to be a powerful and flexible tool for population genetic modeling. However, as a complex piece of software with many features that allow simulating a diverse assortment of evolutionary models, its initial learning curve can be difficult. Here we provide a step-by-step demonstration of how to build a simple evolutionary model in SLiM 3, to help new users get started. We will begin with a panmictic neutral model, and build up to a model of the evolution of a polygenic quantitative trait under selection for an environmental phenotypic optimum.Entities:
Keywords: QTL evolution; modeling tutorial; population genetic simulation
Mesh:
Year: 2019 PMID: 30590560 PMCID: PMC6501880 DOI: 10.1093/molbev/msy237
Source DB: PubMed Journal: Mol Biol Evol ISSN: 0737-4038 Impact factor: 16.240