Literature DB >> 30590481

Discovery of Half-life of Circulating Hepatitis B Surface Antigen in Patients With Chronic Hepatitis B Infection Using Heavy Water Labeling.

Rohit Loomba1, Martin Decaris2, Kelvin W Li2,3, Mahalakshmi Shankaran3, Hussein Mohammed2,3, Marcy Matthews2,3, Lisa M Richards1, Phirum Nguyen1, Emily Rizo1, Barbara Andrews1, Robin Soto1, Thomas Angel3, Vithika Suri4, Kathryn M Kitrinos5, Dwight Barnes6, Gregg Czerwieniec6, Kathy Brendza6, G Mani Subramanian4, Anuj Gaggar4, Marc K Hellerstein2,3.   

Abstract

In a pilot study, heavy water labeling was used to determine hepatitis B surface antigen (HBsAg) turnover rates in chronic hepatitis B (CHB) patients. The mean (standard deviation) half-life of HBsAg in blood was 6.7 (5.5) days, which reflects recent production in the liver and supports strategies aimed at reducing HBsAg production in CHB patients.
© The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  HBV; deuterated water; half-life; hepatitis B surface antigen

Year:  2019        PMID： 30590481     DOI： 10.1093/cid/ciy1100

Source DB:  PubMed          Journal:  Clin Infect Dis        ISSN： 1058-4838            Impact factor:   9.079


  6 in total

1.  Understanding the antiviral effects of RNAi-based therapy in HBeAg-positive chronic hepatitis B infection.

Authors:  Sarah Kadelka; Harel Dahari; Stanca M Ciupe
Journal:  Sci Rep       Date:  2021-01-08       Impact factor: 4.379

2.  Analysis of HBsAg Immunocomplexes and cccDNA Activity During and Persisting After NAP-Based Therapy.

Authors:  Michel Bazinet; Mark Anderson; Victor Pântea; Gheorghe Placinta; Iurie Moscalu; Valentin Cebotarescu; Lilia Cojuhari; Pavlina Jimbei; Liviu Iarovoi; Valentina Smesnoi; Tatina Musteata; Alina Jucov; Ulf Dittmer; Jeff Gersch; Vera Holzmayer; Mary Kuhns; Gavin Cloherty; Andrew Vaillant
Journal:  Hepatol Commun       Date:  2021-07-10

3.  Targeting Subviral Particles: A Critical Step in Achieving HBV Functional Cure but Where Are We with Current Agents in Clinical Development?

Authors:  Andrew Vaillant
Journal:  Viruses       Date:  2022-05-31       Impact factor: 5.818

4.  Modelling hepatitis D virus RNA and HBsAg dynamics during nucleic acid polymer monotherapy suggest rapid turnover of HBsAg.

Authors:  Louis Shekhtman; Scott J Cotler; Leeor Hershkovich; Susan L Uprichard; Michel Bazinet; Victor Pantea; Valentin Cebotarescu; Lilia Cojuhari; Pavlina Jimbei; Adalbert Krawczyk; Ulf Dittmer; Andrew Vaillant; Harel Dahari
Journal:  Sci Rep       Date:  2020-05-12       Impact factor: 4.379

5.  Effect of High-Protein Diets on Integrated Myofibrillar Protein Synthesis before Anterior Cruciate Ligament Reconstruction: A Randomized Controlled Pilot Study.

Authors:  Emily E Howard; Lee M Margolis; Maya A Fussell; Clifford G Rios; Eric M Meisterling; Christopher J Lena; Stefan M Pasiakos; Nancy R Rodriguez
Journal:  Nutrients       Date:  2022-01-27       Impact factor: 5.717

6.  Amplified parallel antigen rapid test for point-of-care salivary detection of SARS-CoV-2 with improved sensitivity.

Authors:  Danny Jian Hang Tng; Khee Chee Soo; Bryan Chu Yang Yin; Jing Cao; Kwan Ki Karrie Ko; Kenneth Choon Meng Goh; Delia Xue Wen Chua; Yong Zhang; Melvin Lee Kiang Chua; Jenny Guek Hong Low; Eng Eong Ooi
Journal:  Mikrochim Acta       Date:  2021-12-06       Impact factor: 5.833
  6 in total

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