| Literature DB >> 30590209 |
Qiang Wang1, Meijia Ren2, Xiaoyong Liu2, Hengchuan Xia2, Keping Chen3.
Abstract
Insects lack an acquired immune system and rely solely on the innate immune system to combat microbial infection. The innate immunity of insects mainly depends on the interaction between the host's pattern recognition receptor (PRR) and pathogen-associated molecular pattern (PAMP). The peptidoglycan recognition proteins (PGRPs) family is the most important pattern recognition receptor (PRR) for insects. It can recognize the main component of the cell wall of the pathogenic microorganism, peptidoglycan (PGN), and plays an important role in the innate immunity of insects. In this paper, the structure, classification, and function of PGRPs is summarized, and the role of PGRPs in the innate immunity of insects is also discussed.Entities:
Keywords: Antimicrobial peptides; Innate immune; The peptidoglycan recognition proteins; Toll, IMD and PPO pathway
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Year: 2018 PMID： 30590209 DOI： 10.1016/j.molimm.2018.12.021
Source DB: PubMed Journal: Mol Immunol ISSN： 0161-5890 Impact factor: 4.407