Literature DB >> 3058804

A 28-kDa protein from Mycobacterium leprae is a target of the human antibody response in lepromatous leprosy.

B J Cherayil1, R A Young.   

Abstract

The gene for a 28-kDa Mycobacterium leprae protein Ag, a major target of antibodies from patients with lepromatous leprosy, was cloned from a lambda-gt11-M. leprae DNA expression library and sequenced. Antibodies to this protein were detected in the serum of the majority of 15 individual lepromatous patients that were tested. The predicted amino acid sequence of the 28-kDa protein suggests that it is localized to the bacterial plasma membrane or cell wall.

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Year:  1988        PMID: 3058804

Source DB:  PubMed          Journal:  J Immunol        ISSN: 0022-1767            Impact factor:   5.422


  17 in total

1.  A major immunogenic 36,000-molecular-weight antigen from Mycobacterium leprae contains an immunoreactive region of proline-rich repeats.

Authors:  J E Thole; L F Stabel; M E Suykerbuyk; M Y De Wit; P R Klatser; A H Kolk; R A Hartskeerl
Journal:  Infect Immun       Date:  1990-01       Impact factor: 3.441

2.  An immunodominant 30-kDa antigen of a candidate anti-leprosy vaccine, Mycobacterium w, shares T and B cell determinants with M. leprae and M. tuberculosis.

Authors:  A Yadava; R Mukherjee
Journal:  Med Microbiol Immunol       Date:  1993-11       Impact factor: 3.402

3.  Isolation and sequencing of the gene coding for an antigenic 34-kilodalton protein of Mycobacterium paratuberculosis.

Authors:  P Gilot; M De Kesel; L Machtelinckx; M Coene; C Cocito
Journal:  J Bacteriol       Date:  1993-08       Impact factor: 3.490

4.  Iron-regulated envelope proteins of mycobacteria grown in vitro and their occurrence in Mycobacterium avium and Mycobacterium leprae grown in vivo.

Authors:  M Sritharan; C Ratledge
Journal:  Biol Met       Date:  1990

5.  Identification and characterization of antigenic determinants of Mycobacterium leprae that react with antibodies in sera of leprosy patients.

Authors:  M Sathish; R E Esser; J E Thole; J E Clark-Curtiss
Journal:  Infect Immun       Date:  1990-05       Impact factor: 3.441

6.  Selection and characterization of recombinant clones that produce Mycobacterium leprae antigens recognized by antibodies in sera from household contacts of leprosy patients.

Authors:  R A Hartskeerl; R M van Rens; L F Stabel; M Y de Wit; P R Klatser
Journal:  Infect Immun       Date:  1990-09       Impact factor: 3.441

7.  Identification of Mycobacterium leprae antigens from a cosmid library: characterization of a 15-kilodalton antigen that is recognized by both the humoral and cellular immune systems in leprosy patients.

Authors:  S Sela; J E Thole; T H Ottenhoff; J E Clark-Curtiss
Journal:  Infect Immun       Date:  1991-11       Impact factor: 3.441

8.  Serology and leprosy: immunoassays comparing immunoglobulin G antibody responses to 28- and 30-kilodalton proteins purified from Mycobacterium bovis BCG.

Authors:  M C Pessolani; J M Peralta; F D Rumjanek; H M Gomes; M A Marques; E C Almeida; M H Saad; E N Sarno
Journal:  J Clin Microbiol       Date:  1991-10       Impact factor: 5.948

9.  Sequence and immunological characterization of a serine-rich antigen from Mycobacterium leprae.

Authors:  F Vega-López; L A Brooks; H M Dockrell; K A De Smet; J K Thompson; R Hussain; N G Stoker
Journal:  Infect Immun       Date:  1993-05       Impact factor: 3.441

10.  Chemical definition, cloning, and expression of the major protein of the leprosy bacillus.

Authors:  B Rivoire; M C Pessolani; C M Bozic; S W Hunter; S A Hefta; V Mehra; P J Brennan
Journal:  Infect Immun       Date:  1994-06       Impact factor: 3.441

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