Deepika Rustogi1, Sangeeta Yadav2, Siddarth Ramji3, T K Mishra4. 1. Department of Pediatrics,Maulana Azad Medical College (University of Delhi), New Delhi, India. 2. Department of Pediatrics, Maulana Azad Medical College (University of Delhi), New Delhi, India. Correspondence to: Dr Sangeeta Yadav, Director Professor, Head, Department of Pediatrics, Maulana Azad Medical College, New Delhi, India. sangeetayadava@gmail.com. 3. Department of Neonatology, Maulana Azad Medical College (University of Delhi), New Delhi, India. 4. Department of Biochemistry, Maulana Azad Medical College (University of Delhi), New Delhi, India.
Abstract
OBJECTIVE: Correlation of catch-up growth and Insulin-like Growth Factor -1 levels (IGF-I) in SGA babies. METHODS: 50 Full-term Small for Gestational Age children aged 12-18 months were analyzed for Catch-up growth (gain in weight and/or length, Standard Deviation Score/SDS >0.67). IGF-1 was measured after post-glucose load using ELISA method and correlated with catch-up growth. RESULTS: Mean (SD) birthweight and length were 2.1 (0.3) Kg and 44.4 (3.1) cm, respectively. At enrollment, mean (SD) age, weight and length were 15.0 (2.1) months, 7.7 (1.3) Kg, and 72.9 (5.6) cm, respectively. Catch-up growth was noted in 60% children. IGF-1 levels were significantly higher in children showing catch-up growth (56.6 (63.2) ng/mL) compared to those not having catch up growth (8.7 (8.3) ng/mL). IGF-1 was positively correlated with both weight and length catch-up. CONCLUSION: Majority of Small for Gestational Age showed catch-up growth by 18 months, which had good correlation with IGF-1 levels.
OBJECTIVE: Correlation of catch-up growth and Insulin-like Growth Factor -1 levels (IGF-I) in SGA babies. METHODS: 50 Full-term Small for Gestational Age children aged 12-18 months were analyzed for Catch-up growth (gain in weight and/or length, Standard Deviation Score/SDS >0.67). IGF-1 was measured after post-glucose load using ELISA method and correlated with catch-up growth. RESULTS: Mean (SD) birthweight and length were 2.1 (0.3) Kg and 44.4 (3.1) cm, respectively. At enrollment, mean (SD) age, weight and length were 15.0 (2.1) months, 7.7 (1.3) Kg, and 72.9 (5.6) cm, respectively. Catch-up growth was noted in 60% children. IGF-1 levels were significantly higher in children showing catch-up growth (56.6 (63.2) ng/mL) compared to those not having catch up growth (8.7 (8.3) ng/mL). IGF-1 was positively correlated with both weight and length catch-up. CONCLUSION: Majority of Small for Gestational Age showed catch-up growth by 18 months, which had good correlation with IGF-1 levels.
Authors: Juan P López-Siguero; Maria J Martínez-Aedo; Jose Antonio Bermúdez de la Vega; Jordi Bosch-Muñoz; Alfonso M Lechuga-Sancho; Triana Villalobos Journal: Clin Endocrinol (Oxf) Date: 2021-12-09 Impact factor: 3.523
Authors: Dmitry O Ivanov; Inna I Evsyukova; Gianluigi Mazzoccoli; George Anderson; Victoria O Polyakova; Igor M Kvetnoy; Annalucia Carbone; Ruslan A Nasyrov Journal: Biology (Basel) Date: 2020-04-05