Joanna Salomon1, Aleksandra Piotrowska2, Łukasz Matusiak1, Piotr Dzięgiel2, Jacek C Szepietowski3. 1. Department of Dermatology, Venereology and Allergology, Wrocław Medical University, Wrocław, Poland. 2. Department of Human Morphology and Embryology, Wrocław Medical University, Wrocław, Poland. 3. Department of Dermatology, Venereology and Allergology, Wrocław Medical University, Wrocław, Poland jacek.szepietowski@umed.wroc.pl.
Abstract
BACKGROUND/AIM: Hidradenitis suppurativa (HS) is a chronic disease. Recently, we suggested, chitinase-3-like protein 1 (YKL-40) as a new biomarker for HS since its serum levels were found to be elevated in patients. The objective of this study was to examine YKL-40 tissue expression in HS. MATERIALS AND METHODS: The study was conducted on 7 patients with HS. The biopsies were obtained from lesional and non-lesional skin. The tissue expression of YKL-40 was assessed using an immunohistochemical method. RESULTS: Inflammatory infiltrates of various grades were visible in all samples of lesional skin. The inflammatory cells within those infiltrates showed a strong cytoplasmic expression of YKL-40. In non-lesional HS skin the pattern of YKL-40 expression was similar to that observed in healthy skin. CONCLUSION: Inflammatory infiltrates in HS skin lesions may be responsible for the elevated YKL-40 serum level. YKL-40 can be considered one of the most valuable biomarkers of HS. Copyright
BACKGROUND/AIM: Hidradenitis suppurativa (HS) is a chronic disease. Recently, we suggested, chitinase-3-like protein 1 (YKL-40) as a new biomarker for HS since its serum levels were found to be elevated in patients. The objective of this study was to examine YKL-40 tissue expression in HS. MATERIALS AND METHODS: The study was conducted on 7 patients with HS. The biopsies were obtained from lesional and non-lesional skin. The tissue expression of YKL-40 was assessed using an immunohistochemical method. RESULTS: Inflammatory infiltrates of various grades were visible in all samples of lesional skin. The inflammatory cells within those infiltrates showed a strong cytoplasmic expression of YKL-40. In non-lesional HS skin the pattern of YKL-40 expression was similar to that observed in healthy skin. CONCLUSION: Inflammatory infiltrates in HS skin lesions may be responsible for the elevated YKL-40 serum level. YKL-40 can be considered one of the most valuable biomarkers of HS. Copyright