Joanna Zając1, Ewa Gomółka2, Wojciech Szot3. 1. Jagiellonian University Medical College, Dep. Hygiene and Dietetics. joanna.jankowska@uj.edu.pl. 2. Toxicological Laboratory, Diagnostics Department, University Hospital, Kraków, Poland. egomolka@su.krakow.pl. 3. Jagiellonian University Medical College, Dep. Hygiene and Dietetics. mcszot@cyf-kr.edu.pl.
Abstract
INTRODUCTION: The aim of presented study was comparison of urinary 1-hydroxypyrene concentration among coke plant workers (before and after working week) and among non-exposed individuals from the same area, taking smoking status into consideration. MATERIAL AND METHODS: 647 coke plant workers and 206 individuals living in the same area were analysed with respect to urinary 1-OHP concentration and smoking status. Urinary samples were measured using high performance liquid chromatography (HPLC) with fluorescent detection. Concentrations were normalized with respect to creatinine concentration. For workers, two samples were collected before and after working week. Multiple regression was performed to distinguish and quantify the influence of cigarette smoking and occupational PAH exposition on the urinary 1-OHP levels. RESULTS: Average urinary 1-OHP concentration of samples collected before the working week was: 1.07 μg/g; after the working week: 2.36 μg/g and for control: 0.74 μg/g. The samples collected at the beginning of the working week were not suitable for assessment of the workers' background (non-occupational) exposition. Smoking cigarettes induced a rise in urinary 1-OHP level by 16%, on average (CI: 5% - 28%), and working for a whole working week at the coke plant made urinary 1-OHP levels, on average, 3.21 times higher (CI: 2.91 - 3.54). CONCLUSIONS: Working at the coke plant increases significantly urinary 1-OHP concentration in comparison to non-occupationally exposed individuals, both for samples collected before and after the working week. Smoking remains a significant source of PAHs exposition, despite the fact that occupational exposure is greater. Health promotion programmes should address both the occupational health risks reduction and smoking prevention.
INTRODUCTION: The aim of presented study was comparison of urinary 1-hydroxypyrene concentration among coke plant workers (before and after working week) and among non-exposed individuals from the same area, taking smoking status into consideration. MATERIAL AND METHODS: 647 coke plant workers and 206 individuals living in the same area were analysed with respect to urinary 1-OHP concentration and smoking status. Urinary samples were measured using high performance liquid chromatography (HPLC) with fluorescent detection. Concentrations were normalized with respect to creatinine concentration. For workers, two samples were collected before and after working week. Multiple regression was performed to distinguish and quantify the influence of cigarette smoking and occupational PAH exposition on the urinary 1-OHP levels. RESULTS: Average urinary 1-OHP concentration of samples collected before the working week was: 1.07 μg/g; after the working week: 2.36 μg/g and for control: 0.74 μg/g. The samples collected at the beginning of the working week were not suitable for assessment of the workers' background (non-occupational) exposition. Smoking cigarettes induced a rise in urinary 1-OHP level by 16%, on average (CI: 5% - 28%), and working for a whole working week at the coke plant made urinary 1-OHP levels, on average, 3.21 times higher (CI: 2.91 - 3.54). CONCLUSIONS: Working at the coke plant increases significantly urinary 1-OHP concentration in comparison to non-occupationally exposed individuals, both for samples collected before and after the working week. Smoking remains a significant source of PAHs exposition, despite the fact that occupational exposure is greater. Health promotion programmes should address both the occupational health risks reduction and smoking prevention.
Authors: Henriqueta Louro; Bruno Costa Gomes; Anne Thoustrup Saber; Anna Laura Iamiceli; Thomas Göen; Kate Jones; Andromachi Katsonouri; Christiana M Neophytou; Ulla Vogel; Célia Ventura; Axel Oberemm; Radu Corneliu Duca; Mariana F Fernandez; Nicolas Olea; Tiina Santonen; Susana Viegas; Maria João Silva Journal: Toxics Date: 2022-08-17