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Literature DB >> 30586301

Dynamic Carbon Isotope Exchange of Pharmaceuticals with Labeled CO₂.

Gianluca Destro¹, Olivier Loreau¹, Elodie Marcon¹, Frédéric Taran¹, Thibault Cantat², Davide Audisio¹.

Abstract

A copper-catalyzed procedure enabling dynamic carbon isotope exchange is described. Utilizing the universal precursor [14C]CO2, this protocol allows to insert, in one single step, the desired carbon tag into carboxylic acids with no need of structural modifications. Reducing synthetic costs and limiting the generation of radioactive waste, this procedure will facilitate the access to carboxylic acids containing drugs and accelerate early 14C-based ADME studies supporting drug development.

Entities: Chemical

Mesh：

Substances：

Year: 2018 PMID： 30586301 DOI： 10.1021/jacs.8b12140

Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419

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Cited

4 in total

1. Origin of Free Energy Barriers of Decarboxylation and the Reverse Process of CO₂ Capture in Dimethylformamide and in Water.

Authors: Shaoyuan Zhou; Bach T Nguyen; John P Richard; Ronald Kluger; Jiali Gao
Journal: J Am Chem Soc Date: 2020-12-29 Impact factor: 15.419

Dynamic Carbon Isotope Exchange of Pharmaceuticals with Labeled CO₂.

1. Origin of Free Energy Barriers of Decarboxylation and the Reverse Process of CO₂ Capture in Dimethylformamide and in Water.

Review 2. The Emergence of Carbon Isotope Exchange.

Review 3. Late-Stage Carbon-14 Labeling and Isotope Exchange: Emerging Opportunities and Future Challenges.

4. Carbon-11 carboxylation of trialkoxysilane and trimethylsilane derivatives using [¹¹C]CO₂.

Dynamic Carbon Isotope Exchange of Pharmaceuticals with Labeled CO2.

1. Origin of Free Energy Barriers of Decarboxylation and the Reverse Process of CO2 Capture in Dimethylformamide and in Water.

Review 2. The Emergence of Carbon Isotope Exchange.

Review 3. Late-Stage Carbon-14 Labeling and Isotope Exchange: Emerging Opportunities and Future Challenges.

4. Carbon-11 carboxylation of trialkoxysilane and trimethylsilane derivatives using [11C]CO2.

Dynamic Carbon Isotope Exchange of Pharmaceuticals with Labeled CO₂.

1. Origin of Free Energy Barriers of Decarboxylation and the Reverse Process of CO₂ Capture in Dimethylformamide and in Water.

4. Carbon-11 carboxylation of trialkoxysilane and trimethylsilane derivatives using [¹¹C]CO₂.