| Literature DB >> 30585518 |
Yun-Yao Kang1, Yan-Bei Tu1, Chao Zhu1, Xue-Fei Meng1, Yang Yan1, Chuan-Hai Wu1, Yan-Fang Li1.
Abstract
Two new stilbenoids bletilol D (1) and bletilol E (2), together with five known compounds were isolated from Bletilla striata. Three of them (3, 4, and 7) were obtained from this genus for the first time. Their structures were elucidated by spectroscopic methods and comparing with data reported in literatures. The cytotoxic activities of compounds 1-7 against MCF-7 (human breast cancer) and A549 (human lung carcinoma) cell lines were evaluated by MTT assay. Compound 2 showed weak cytotoxicity against MCF-7 and A549 cell lines with IC50 values of 36.32 ± 1.17 and 36.48 ± 1.12 μM, respectively, and 5 exhibited weak cytotoxicity against MCF-7 cell line with IC50 value of 57.09 ± 2.03 μM.Entities:
Keywords: Bletilla striata; Orchidaceae; bletilol D; bletilol E; cytotoxicity; stilbenoid
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Year: 2018 PMID: 30585518 DOI: 10.1080/10286020.2018.1526787
Source DB: PubMed Journal: J Asian Nat Prod Res ISSN: 1028-6020 Impact factor: 1.569