Literature DB >> 30585518

Two new stilbenoids from Bletilla striata.

Yun-Yao Kang1, Yan-Bei Tu1, Chao Zhu1, Xue-Fei Meng1, Yang Yan1, Chuan-Hai Wu1, Yan-Fang Li1.   

Abstract

Two new stilbenoids bletilol D (1) and bletilol E (2), together with five known compounds were isolated from Bletilla striata. Three of them (3, 4, and 7) were obtained from this genus for the first time. Their structures were elucidated by spectroscopic methods and comparing with data reported in literatures. The cytotoxic activities of compounds 1-7 against MCF-7 (human breast cancer) and A549 (human lung carcinoma) cell lines were evaluated by MTT assay. Compound 2 showed weak cytotoxicity against MCF-7 and A549 cell lines with IC50 values of 36.32 ± 1.17 and 36.48 ± 1.12 μM, respectively, and 5 exhibited weak cytotoxicity against MCF-7 cell line with IC50 value of 57.09 ± 2.03 μM.

Entities:  

Keywords:  Bletilla striata; Orchidaceae; bletilol D; bletilol E; cytotoxicity; stilbenoid

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Year:  2018        PMID: 30585518     DOI: 10.1080/10286020.2018.1526787

Source DB:  PubMed          Journal:  J Asian Nat Prod Res        ISSN: 1028-6020            Impact factor:   1.569


  2 in total

Review 1.  Orchidaceae-Derived Anticancer Agents: A Review.

Authors:  Tomasz Śliwiński; Tomasz Kowalczyk; Przemysław Sitarek; Marta Kolanowska
Journal:  Cancers (Basel)       Date:  2022-01-31       Impact factor: 6.639

2.  Biological evaluation, molecular modeling and dynamics simulation of phenanthrenes isolated from Bletilla striata as butyrylcholinesterase inhibitors.

Authors:  Yi Liu; Yanbei Tu; Yunyao Kang; Chao Zhu; Chuanhai Wu; Gang Chen; Zerong Liu; Yanfang Li
Journal:  Sci Rep       Date:  2022-08-11       Impact factor: 4.996

  2 in total

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