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Literature DB >> 305854

Effects of the antiprotease Trasylol on peripheral blood leucocytes.

A W Thomson, R G Pugh-Humphreys, D J Tweedie, C H Horne.

Abstract

Binding of the antiprotease Trasylol to human peripheral blood lymphocytes and polymorphonuclear leucocytes (PMNs) was demonstrated at the ultrastructural level using an indirect immunoperoxidase technique. This also revealed endocytosis of membrane bound Trasylol by PMNs. Trasylol inhibited PHA- and ConA-induced lymphocyte stimulation, and was cytotoxic to unstimulated cells.

Entities: Gene Species

Mesh：

Substances：
Aprotinin
Peroxidases

Year: 1978 PMID： 305854 DOI： 10.1007/bf01935971

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

15 in total

1. Interaction between lymphocytes and inflammatory exudate cells. II. A proteolytic enzyme released by PMN as a possible mediator for enhancement of thymocyte response.

Authors: S Nakamura; M Yoshinaga; H Hayashi
Journal: J Immunol Date: 1976-07 Impact factor: 5.422

2. Isolation of lymphocytes, granulocytes and macrophages.

Authors: A Bøyum
Journal: Scand J Immunol Date: 1976-06 Impact factor: 3.487

3. Fluorescent-labelled aprotinin: a new reagent for the histochemical detection of acid mucosubstances.

Authors: J A Kiernan; R W Stoddart
Journal: Histochemie Date: 1973

4. Involvement of proteolytic acivity in early events in lymphocyte transformation by phytohemagglutinin.

Authors: M Saito; T Yoshizawa; T Aoyagi; Y Nagai
Journal: Biochem Biophys Res Commun Date: 1973-05-15 Impact factor: 3.575

5. Letter: T-cell origin of acid-phosphatase-positive lymphoblasts.

Authors: D Catovsky
Journal: Lancet Date: 1975-08-16 Impact factor: 79.321

6. The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique.

Authors: R C Graham; M J Karnovsky
Journal: J Histochem Cytochem Date: 1966-04 Impact factor: 2.479

7. The effect of epsilon amino caproic acid and other inhibitors of proteolysis upon the response of human peripheral blood lymphocytes to phytohemagglutinin.

Authors: R Hirschhorn; J Grossman; W Troll; G Weissmann
Journal: J Clin Invest Date: 1971-06 Impact factor: 14.808

8. The use of lead citrate at high pH as an electron-opaque stain in electron microscopy.

Authors: E S REYNOLDS
Journal: J Cell Biol Date: 1963-04 Impact factor: 10.539

9. Differences in enzyme content of azurophil and specific granules of polymorphonuclear leukocytes. I. Histochemical staining of bone marrow smears.

Authors: D F Bainton; M G Farquhar
Journal: J Cell Biol Date: 1968-11 Impact factor: 10.539

10. Studies on lysosomes. XII. Redistribution of acid hydrolases in human lymphocytes stimulated by phytohemagglutinin.

Authors: R Hirschhorn; G Brittinger; K Hirschhorn; G Weissmann
Journal: J Cell Biol Date: 1968-05 Impact factor: 10.539

8 in total

1. Inhibition of neutrophil-mediated cytotoxicity by alpha 2 macroglobulin.

Authors: G Cordier; J P Revillard
Journal: Experientia Date: 1980-05-15

2. The in vitro effect of aprotinin upon spleen cells from normal and tumour-bearing mice exposed to PPD and tumour cells.

Authors: J G Freeman; A L Latner; G A Turner; C W Venables
Journal: Experientia Date: 1980-02-15

Effects of the antiprotease Trasylol on peripheral blood leucocytes.

1. Interaction between lymphocytes and inflammatory exudate cells. II. A proteolytic enzyme released by PMN as a possible mediator for enhancement of thymocyte response.

2. Isolation of lymphocytes, granulocytes and macrophages.

3. Fluorescent-labelled aprotinin: a new reagent for the histochemical detection of acid mucosubstances.

4. Involvement of proteolytic acivity in early events in lymphocyte transformation by phytohemagglutinin.

5. Letter: T-cell origin of acid-phosphatase-positive lymphoblasts.

6. The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique.

7. The effect of epsilon amino caproic acid and other inhibitors of proteolysis upon the response of human peripheral blood lymphocytes to phytohemagglutinin.

8. The use of lead citrate at high pH as an electron-opaque stain in electron microscopy.

9. Differences in enzyme content of azurophil and specific granules of polymorphonuclear leukocytes. I. Histochemical staining of bone marrow smears.

10. Studies on lysosomes. XII. Redistribution of acid hydrolases in human lymphocytes stimulated by phytohemagglutinin.

1. Inhibition of neutrophil-mediated cytotoxicity by alpha 2 macroglobulin.

2. The in vitro effect of aprotinin upon spleen cells from normal and tumour-bearing mice exposed to PPD and tumour cells.

3. Cell surface protease activity of human lymphocytes; its inhibition by alpha 1-antitrypsin.

4. Lymphocyte stimulation in vitro by proteinases and its augmentation with a proteinase binding factor from human skin.

5. On the biological role of a proteolytic-enzyme inhibitor from the ectoparasitic tick Boophilus microplus.

6. Interaction between alpha 1 antitrypsin and lymphocyte surface proteases: immunoregulatory effects.

7. TEEM-test studies on effect of aprotinin on in vitro response of cancer patients' lymphocytes to PPD.

8. Endocytosis of the antiprotease aprotinin by Landschütz ascites carcinoma cells and its effects in vitro and in vivo.