Literature DB >> 3058538

Analgesic activity of flupirtine maleate: a controlled double-blind study with diclofenac sodium in orthopaedics.

P Mastronardi1, M D'Onofrio, E Scanni, M Pinto, S Frontespezi, M G Ceccarelli, F Bianchi, B Mazzarella.   

Abstract

A controlled, parallel group study of the analgesic efficacy of flupirtine maleate, was compared against diclofenac sodium in 40 orthopaedic patients with post-operative pain. Clinically, both drugs were of equal analgesic efficacy. A mathematical model has been developed, however, to evaluate the speed, intensity and duration of the analgesic effect and provides data which significantly favour flupirtine maleate in the treatment of these patients.

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Year:  1988        PMID: 3058538     DOI: 10.1177/030006058801600503

Source DB:  PubMed          Journal:  J Int Med Res        ISSN: 0300-0605            Impact factor:   1.671


  12 in total

Review 1.  Single dose oral ibuprofen for acute postoperative pain in adults.

Authors:  Christopher Derry; Sheena Derry; R Andrew Moore; Henry J McQuay
Journal:  Cochrane Database Syst Rev       Date:  2009-07-08

2.  Concomitant facilitation of GABAA receptors and KV7 channels by the non-opioid analgesic flupirtine.

Authors:  Felicia Klinger; Petra Geier; Mario M Dorostkar; Giri K Chandaka; Arsalan Yousuf; Isabella Salzer; Helmut Kubista; Stefan Boehm
Journal:  Br J Pharmacol       Date:  2012-07       Impact factor: 8.739

Review 3.  Flupirtine in pain management: pharmacological properties and clinical use.

Authors:  Jacques Devulder
Journal:  CNS Drugs       Date:  2010-10       Impact factor: 5.749

Review 4.  Flupirtine. A review of its pharmacological properties, and therapeutic efficacy in pain states.

Authors:  H A Friedel; A Fitton
Journal:  Drugs       Date:  1993-04       Impact factor: 9.546

5.  Flupirtine: Clinical pharmacology.

Authors:  S Harish; K Bhuvana; Girish M Bengalorkar; Tn Kumar
Journal:  J Anaesthesiol Clin Pharmacol       Date:  2012-04

Review 6.  Single-dose intravenous diclofenac for acute postoperative pain in adults.

Authors:  Ewan D McNicol; McKenzie C Ferguson; Roman Schumann
Journal:  Cochrane Database Syst Rev       Date:  2018-08-28

7.  Role of flupirtine as a preemptive analgesic in patients undergoing laparoscopic cholecystectomy.

Authors:  Ghanshyam Yadav; Shailaja Shankar Behera; Saurabh Kumar Das; Gaurav Jain; Sujali Choupoo; Janak Raj
Journal:  J Anaesthesiol Clin Pharmacol       Date:  2015 Apr-Jun

8.  Potassium channels in peripheral pain pathways: expression, function and therapeutic potential.

Authors:  Xiaona Du; Nikita Gamper
Journal:  Curr Neuropharmacol       Date:  2013-12       Impact factor: 7.363

9.  Activation of peripheral KCNQ channels attenuates inflammatory pain.

Authors:  Hiroki Hayashi; Masashi Iwata; Noboru Tsuchimori; Tatsumi Matsumoto
Journal:  Mol Pain       Date:  2014-02-21       Impact factor: 3.395

10.  Effect of flupirtine on the growth and viability of U373 malignant glioma cells.

Authors:  Elango Panchanathan; Gnanasambandan Ramanathan; Bhaskar Venkata Kameswara Subrahmanya Lakkakula
Journal:  Cancer Biol Med       Date:  2013-09       Impact factor: 4.248

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