Ji Liu1, Shenglei Zhang2, Jiaxuan Chen3, Yiping Mao4, Xiaoqing Shao5, Yang Li5, Jianmei Cao6, Wei Zheng6, Bing Zhang6, Zhiyong Zong7. 1. School of Nursing, Xuzhou Medical University, Xuzhou, China; Emergency Intensive Care Unit, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China. 2. Intensive Care Unit, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China. 3. School of Clinical Medicine, Xuzhou Medical University, Xuzhou, China. 4. Department of Nosocomial Infection Management, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China. Electronic address: 3228137778@qq.com. 5. School of Nursing, Xuzhou Medical University, Xuzhou, China. 6. Department of Nosocomial Infection Management, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China. 7. Department of Infection Control, West China Hospital, Sichuan University, Chengdu, China; Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China.
Abstract
BACKGROUND: In January 2013, the Centers for Disease Control and Prevention released new surveillance definitions for ventilator-associated event (VAE) to replace ventilator-associated pneumonia (VAP) in adult patients. VAEs are associated with prolonged mechanical ventilation and hospital death, but little is known about their risk factors and how best to prevent them. METHODS: We compared VAE cases with non-VAE cases with regard to demographics, comorbidities, sedative exposures, opioids exposures, paralytic exposures, routes of nutrition, blood products, gastric retention, and fluid balance. Patients mechanically ventilated for ≥4 days between January 1, 2017, and December 31, 2017, in 2 adult intensive care units of a tertiary care teaching hospital in China were included. RESULTS: On multivariable logistic regression, significant risk factors for VAEs were positive daily fluid balances of ≥ 50 mL between day of intubation and the fourth day of mechanical ventilation (relative risk [RR], 8.39; 95% confidence interval [CI], 2.99-23.50), sedative administered between the first day and the fourth day of invasive mechanical ventilation (RR, 15.69; 95% CI, 1.62-152.06), and daily gastric retention of ≥200 mL between day of intubation and the fourth day of mechanical ventilation (RR, 9.27; 95% CI, 1.89-45.47). CONCLUSIONS: Positive daily fluid balances of ≥50 mL, sedatives administered, and gastric retention of ≥200 mL are risk factors for VAEs. Intervention studies are needed to determine if targeting these risk factors can lower VAE rates.
BACKGROUND: In January 2013, the Centers for Disease Control and Prevention released new surveillance definitions for ventilator-associated event (VAE) to replace ventilator-associated pneumonia (VAP) in adult patients. VAEs are associated with prolonged mechanical ventilation and hospital death, but little is known about their risk factors and how best to prevent them. METHODS: We compared VAE cases with non-VAE cases with regard to demographics, comorbidities, sedative exposures, opioids exposures, paralytic exposures, routes of nutrition, blood products, gastric retention, and fluid balance. Patients mechanically ventilated for ≥4 days between January 1, 2017, and December 31, 2017, in 2 adult intensive care units of a tertiary care teaching hospital in China were included. RESULTS: On multivariable logistic regression, significant risk factors for VAEs were positive daily fluid balances of ≥ 50 mL between day of intubation and the fourth day of mechanical ventilation (relative risk [RR], 8.39; 95% confidence interval [CI], 2.99-23.50), sedative administered between the first day and the fourth day of invasive mechanical ventilation (RR, 15.69; 95% CI, 1.62-152.06), and daily gastric retention of ≥200 mL between day of intubation and the fourth day of mechanical ventilation (RR, 9.27; 95% CI, 1.89-45.47). CONCLUSIONS: Positive daily fluid balances of ≥50 mL, sedatives administered, and gastric retention of ≥200 mL are risk factors for VAEs. Intervention studies are needed to determine if targeting these risk factors can lower VAE rates.