Literature DB >> 30583881

Minimal inhibitory concentration of omadacycline and doxycycline against bacterial isolates with known tetracycline resistance determinants.

Ad C Fluit1, Sjoukje van Gorkum2, Judith Vlooswijk2.   

Abstract

Omadacycline is an aminomethylcycline derived from the tetracycline class. The minimum inhibitory concentration of 115 Enterobacteriaceae and Staphylococcus aureus isolates with known tetracycline resistance determinants against omadacycline and doxycycline was determined by broth microdilution. Omadacycline is, on a weight basis, more active than doxycycline for nearly all isolates, and differences in activity correlated with organism rather than resistance mechanism.
Copyright © 2018 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Doxycycline; MIC; Omadacycline; Resistance

Mesh：

Substances：

Year:  2018        PMID： 30583881     DOI： 10.1016/j.diagmicrobio.2018.11.010

Source DB:  PubMed          Journal:  Diagn Microbiol Infect Dis        ISSN： 0732-8893            Impact factor:   2.803


  5 in total

1.  In vitro activity of omadacycline against pathogens isolated from Mainland China during 2017-2018.

Authors:  Dong Dong; Yonggui Zheng; Qingqing Chen; Yan Guo; Yang Yang; Shi Wu; Demei Zhu; Daniel Deng; Patricia A Bradford; Harald Reinhart; Fupin Hu
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2020-04-30       Impact factor: 3.267

2.  Multilaboratory Comparison of Omadacycline MIC Test Strip to Broth Microdilution MIC against Gram-Negative, Gram-Positive, and Fastidious Bacteria.

Authors:  L K Koeth; J M DiFranco-Fisher; D J Hardy; E L Palavecino; E Carretto; A Windau
Journal:  J Clin Microbiol       Date:  2021-10-06       Impact factor: 11.677

Review 3.  Antimicrobial resistance in methicillin-resistant Staphylococcus aureus to newer antimicrobial agents.

Authors:  Richard R Watkins; Marisa Holubar; Michael Z David
Journal:  Antimicrob Agents Chemother       Date:  2019-09-16       Impact factor: 5.191

Review 4.  Use of oral tetracyclines in the treatment of adult outpatients with skin and skin structure infections: Focus on doxycycline, minocycline, and omadacycline.

Authors:  Monique R Bidell; Thomas P Lodise
Journal:  Pharmacotherapy       Date:  2021-10-05       Impact factor: 6.251

5.  In Vitro Activity of Omadacycline, a New Tetracycline Analog, and Comparators against Clostridioides difficile.

Authors:  Khurshida Begum; Eugénie Bassères; Julie Miranda; Chris Lancaster; Anne J Gonzales-Luna; Travis J Carlson; Tasnuva Rashid; David W Eyre; Mark H Wilcox; M Jahangir Alam; Kevin W Garey
Journal:  Antimicrob Agents Chemother       Date:  2020-07-22       Impact factor: 5.191
  5 in total

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