Ki-Bum Won1, Sang-Eun Lee2, Byoung Kwon Lee3, Hyung-Bok Park4, Ran Heo5, Asim Rizvi6, Fay Y Lin7, Amit Kumar7, Martin Hadamitzky8, Yong-Jin Kim9, Ji Min Sung2, Edoardo Conte10, Daniele Andreini10, Gianluca Pontone10, Matthew J Budoff11, Ilan Gottlieb12, Eun Ju Chun13, Filippo Cademartiri14, Erica Maffei15, Hugo Marques16, Jonathon A Leipsic17, Sanghoon Shin18, Jung Hyun Choi19, Renu Virmani20, Habib Samady21, Kavitha Chinnaiyan22, Gilbert L Raff22, Peter H Stone23, Daniel S Berman24, Jagat Narula25, Leslee J Shaw7, Jeroen J Bax26, James K Min7, Hyuk-Jae Chang27. 1. Department of Cardiology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea; Department of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Yonsei University Health System, Seoul, South Korea. 2. Department of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Yonsei University Health System, Seoul, South Korea; Yonsei-Cedars-Sinai Integrative Cardiovascular Imaging Research Center, Yonsei University College of Medicine, Yonsei University Health System, Seoul, South Korea. 3. Department of Cardiology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea. 4. Yonsei-Cedars-Sinai Integrative Cardiovascular Imaging Research Center, Yonsei University College of Medicine, Yonsei University Health System, Seoul, South Korea; Department of Cardiology, Catholic Kwandong University International St. Mary's Hospital, Incheon, South Korea. 5. Yonsei-Cedars-Sinai Integrative Cardiovascular Imaging Research Center, Yonsei University College of Medicine, Yonsei University Health System, Seoul, South Korea; Department of Cardiology, Hanyang University Seoul Hospital, Hanyang University College of Medicine, Seoul, South Korea. 6. Department of Radiology, New York-Presbyterian Hospital and Weill Cornell Medical College, New York, NY, USA; Department of Radiology, Mayo Clinic, Rochester, MN, USA. 7. Department of Radiology, New York-Presbyterian Hospital and Weill Cornell Medical College, New York, NY, USA. 8. Department of Radiology and Nuclear Medicine, German Heart Center Munich, Munich, Germany. 9. Seoul National University Hospital, Seoul, South Korea. 10. Centro Cardiologico Monzino, IRCCS, Milan, Italy. 11. Department of Medicine, Los Angeles Biomedical Research Institute, Torrance, CA, USA. 12. Department of Radiology, Casa de Saude São Jose, Rio de Janeiro, Brazil. 13. Department of Radiology, Seoul National University Bundang Hospital, Sungnam, South Korea. 14. Cardiovascular Imaging Center, SDN IRCCS, Naples, Italy. 15. Department of Radiology, Area Vasta 1/ASUR Marche, Urbino, Italy. 16. UNICA, Unit of Cardiovascular Imaging, Hospital da Luz, Lisboa, Portugal. 17. Department of Medicine and Radiology, University of British Columbia, Vancouver, BC, Canada. 18. Department of Cardiology, National Health Insurance Service Ilsan Hospital, South Korea. 19. Department of Cardiology, Busan University Hospital, Busan, South Korea. 20. Department of Pathology, CVPath Institute, Gaithersburg, MD, USA. 21. Department of Cardiology, Emory University School of Medicine, Atlanta, GA, USA. 22. Department of Cardiology, William Beaumont Hospital, Royal Oak, MI, USA. 23. Department of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. 24. Department of Imaging and Medicine, Cedars Sinai Medical Center, Los Angeles, CA, USA. 25. Icahn School of Medicine at Mount Sinai, Mount Sinai Heart, Zena and Michael A. Wiener Cardiovascular Institute, And Marie-Josee and Henry R. Kravis Center for Cardiovascular Health, New York, NY, USA. 26. Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands. 27. Department of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Yonsei University Health System, Seoul, South Korea; Yonsei-Cedars-Sinai Integrative Cardiovascular Imaging Research Center, Yonsei University College of Medicine, Yonsei University Health System, Seoul, South Korea. Electronic address: hjchang@yuhs.ac.
Abstract
BACKGROUND: Data on the impact of glycemic status on coronary plaque progression have been limited. This study evaluated the association between glycemic status and coronary plaque volume change (PVC) using coronary computed tomography angiography (CCTA). METHODS: A total of 1296 subjects (61 ± 9, 56.9% male) who underwent serial CCTA with available glycemic status were enrolled and analyzed from the Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry. The median inter-scan period was 3.2 (2.6-4.4) years. Quantitative assessment of coronary plaques was performed at both scans. All participants were categorized into the following groups according to glycemic status: normal, pre-diabetes (pre-DM), and diabetes mellitus (DM). RESULTS: During the follow-up, significant differences in PVC (normal: 51.3 ± 83.3 mm3 vs. pre-DM: 51.0 ± 84.3 mm3 vs. DM: 72.6 ± 95.0 mm3; p < 0.001) and annualized PVC (normal: 14.9 ± 24.9 mm3 vs. pre-DM: 15.7 ± 23.8 mm3 vs. DM: 21.0 ± 27.7 mm3; p = 0.001) were observed among the 3 groups. Compared with normal individuals, individuals with pre-DM showed no significant differences in the adjusted odds ratio (OR) for plaque progression (PP) (1.338, 95% confidence interval [CI] 0.967-1.853; p = 0.079). However, the adjusted OR for PP was higher in DM individuals than in normal individuals (1.635, 95% CI 1.126-2.375; p = 0.010). CONCLUSION: DM had an incremental impact on coronary PP, but pre-DM appeared to have no significant association with an increased risk of coronary PP after adjusting for confounding factors. CLINICAL TRIAL REGISTRATION: ClinicalTrials.govNCT02803411.
BACKGROUND: Data on the impact of glycemic status on coronary plaque progression have been limited. This study evaluated the association between glycemic status and coronary plaque volume change (PVC) using coronary computed tomography angiography (CCTA). METHODS: A total of 1296 subjects (61 ± 9, 56.9% male) who underwent serial CCTA with available glycemic status were enrolled and analyzed from the Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry. The median inter-scan period was 3.2 (2.6-4.4) years. Quantitative assessment of coronary plaques was performed at both scans. All participants were categorized into the following groups according to glycemic status: normal, pre-diabetes (pre-DM), and diabetes mellitus (DM). RESULTS: During the follow-up, significant differences in PVC (normal: 51.3 ± 83.3 mm3 vs. pre-DM: 51.0 ± 84.3 mm3 vs. DM: 72.6 ± 95.0 mm3; p < 0.001) and annualized PVC (normal: 14.9 ± 24.9 mm3 vs. pre-DM: 15.7 ± 23.8 mm3 vs. DM: 21.0 ± 27.7 mm3; p = 0.001) were observed among the 3 groups. Compared with normal individuals, individuals with pre-DM showed no significant differences in the adjusted odds ratio (OR) for plaque progression (PP) (1.338, 95% confidence interval [CI] 0.967-1.853; p = 0.079). However, the adjusted OR for PP was higher in DM individuals than in normal individuals (1.635, 95% CI 1.126-2.375; p = 0.010). CONCLUSION: DM had an incremental impact on coronary PP, but pre-DM appeared to have no significant association with an increased risk of coronary PP after adjusting for confounding factors. CLINICAL TRIAL REGISTRATION: ClinicalTrials.govNCT02803411.
Authors: Ki-Bum Won; Byoung Kwon Lee; Hyung-Bok Park; Ran Heo; Sang-Eun Lee; Asim Rizvi; Fay Y Lin; Amit Kumar; Martin Hadamitzky; Yong-Jin Kim; Ji Min Sung; Edoardo Conte; Daniele Andreini; Gianluca Pontone; Matthew J Budoff; Ilan Gottlieb; Eun Ju Chun; Filippo Cademartiri; Erica Maffei; Hugo Marques; Pedro de Araújo Gonçalves; Jonathon A Leipsic; Sanghoon Shin; Jung Hyun Choi; Renu Virmani; Habib Samady; Kavitha Chinnaiyan; Gilbert L Raff; Peter H Stone; Daniel S Berman; Jagat Narula; Leslee J Shaw; Jeroen J Bax; James K Min; Hyuk-Jae Chang Journal: Cardiovasc Diabetol Date: 2020-07-18 Impact factor: 9.951
Authors: Matthew J Budoff; Suvasini Lakshmanan; Peter P Toth; Harvey S Hecht; Leslee J Shaw; David J Maron; Erin D Michos; Kim A Williams; Khurram Nasir; Andrew D Choi; Kavitha Chinnaiyan; James Min; Michael Blaha Journal: Am J Prev Cardiol Date: 2022-01-20