Elizabeth Andersen1, Alana Campbell2, Susan Girdler3, Kelly Duffy4, Aysenil Belger5. 1. Department of Psychiatry, CB# 7160, University of North Carolina, Chapel Hill, NC 27599-7160, USA. Electronic address: Elizabeth_Andersen@med.unc.edu. 2. Department of Psychiatry, CB# 7160, University of North Carolina, Chapel Hill, NC 27599-7160, USA. Electronic address: Alana_Campbell@med.unc.edu. 3. Department of Psychiatry, CB# 7160, University of North Carolina, Chapel Hill, NC 27599-7160, USA. Electronic address: Susan_Girdler@med.unc.edu. 4. Department of Psychiatry, CB# 7160, University of North Carolina, Chapel Hill, NC 27599-7160, USA. 5. Department of Psychiatry, CB# 7160, University of North Carolina, Chapel Hill, NC 27599-7160, USA; Brain Imaging and Analysis Center, CB# 3918, Duke University, Durham, NC 27710, USA. Electronic address: Aysenil_Belger@med.unc.edu.
Abstract
OBJECTIVE: The current study evaluated the differential impact of acute psychosocial stress exposure on oscillatory correlates of affective processing in control participants and patients with schizophrenia spectrum disorders (SCZ) to elucidate the stress-mediated pathway to psychopathology. METHODS: EEG was recorded while 21 control participants and 21 patients with SCZ performed emotional framing tasks (assessing a key aspect of emotion regulation (ER)) before and after a laboratory stress challenge (Trier Social Stress Test). EEG spectral perturbations evoked in response to neutral and aversive stimuli (presented with positive or negative contextual cues) were extracted in theta (4-8 Hz) and beta (12-30 Hz) frequencies. RESULTS: Patients demonstrated aberrant theta and beta oscillatory activity, with impaired frontal theta-mediated framing and beta-derived motivated attention processes relative to controls. Following stress exposure, controls exhibited impaired frontal theta-mediated emotional framing, similar to the oscillatory profile observed in patients before stress. CONCLUSIONS: The acute stress-induced oscillatory changes observed in controls were persistently present in patients, indicating an inefficiency of fronto-limbic adaptation to stress exposure. SIGNIFICANCE: Results provide novel insight on the electrophysiological correlates of arousal and affect regulation, which are core homogeneous symptom dimensions shared across neuropsychiatric disorders, and shed light on putative mechanisms in the translation of stress into psychopathology.
OBJECTIVE: The current study evaluated the differential impact of acute psychosocial stress exposure on oscillatory correlates of affective processing in control participants and patients with schizophrenia spectrum disorders (SCZ) to elucidate the stress-mediated pathway to psychopathology. METHODS: EEG was recorded while 21 control participants and 21 patients with SCZ performed emotional framing tasks (assessing a key aspect of emotion regulation (ER)) before and after a laboratory stress challenge (Trier Social Stress Test). EEG spectral perturbations evoked in response to neutral and aversive stimuli (presented with positive or negative contextual cues) were extracted in theta (4-8 Hz) and beta (12-30 Hz) frequencies. RESULTS:Patients demonstrated aberrant theta and beta oscillatory activity, with impaired frontal theta-mediated framing and beta-derived motivated attention processes relative to controls. Following stress exposure, controls exhibited impaired frontal theta-mediated emotional framing, similar to the oscillatory profile observed in patients before stress. CONCLUSIONS: The acute stress-induced oscillatory changes observed in controls were persistently present in patients, indicating an inefficiency of fronto-limbic adaptation to stress exposure. SIGNIFICANCE: Results provide novel insight on the electrophysiological correlates of arousal and affect regulation, which are core homogeneous symptom dimensions shared across neuropsychiatric disorders, and shed light on putative mechanisms in the translation of stress into psychopathology.
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