Literature DB >> 30578089

Transcriptional and Epigenetic Regulation of Microglia in Health and Disease.

Hana Yeh1, Tsuneya Ikezu2.   

Abstract

Microglia are the resident immune cells that maintain brain homeostasis and contribute to neurodegenerative disorders. Recent studies of microglia at transcriptomic and epigenetic levels revealed specific molecular pathways that regulate microglia development, maturation, and reactive states. The transcription factor PU.1 plays a key role in regulating several microglial functions. Environmental factors such as microbiota, early life stress, and maternal immune activation can dysregulate PU.1 and innate immune response. This review discusses the epigenetic regulation of key transcriptional factors in human and murine microglia, highlighting their networks for shaping the microglial function. PU.1 and other microglia-specific transcriptional factors can be further studied to determine their therapeutic applications in neurologic disorders.
Copyright © 2018 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  PU.1; microglia; microglia transcription; neurodegenerative disorders

Mesh：

Substances：

Year:  2018        PMID： 30578089      PMCID： PMC6377292          DOI： 10.1016/j.molmed.2018.11.004

Source DB:  PubMed          Journal:  Trends Mol Med        ISSN： 1471-4914            Impact factor:   11.951


  88 in total

1.  Generation of a microglial developmental index in mice and in humans reveals a sex difference in maturation and immune reactivity.

Authors:  Richa Hanamsagar; Mark D Alter; Carina S Block; Haley Sullivan; Jessica L Bolton; Staci D Bilbo
Journal:  Glia       Date:  2017-06-15       Impact factor: 7.452

2.  Diverse Requirements for Microglial Survival, Specification, and Function Revealed by Defined-Medium Cultures.

Authors:  Christopher J Bohlen; F Chris Bennett; Andrew F Tucker; Hannah Y Collins; Sara B Mulinyawe; Ben A Barres
Journal:  Neuron       Date:  2017-05-17       Impact factor: 17.173

Review 3.  Immune attack: the role of inflammation in Alzheimer disease.

Authors:  Frank L Heppner; Richard M Ransohoff; Burkhard Becher
Journal:  Nat Rev Neurosci       Date:  2015-06       Impact factor: 34.870

4.  A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease.

Authors:  Hadas Keren-Shaul; Amit Spinrad; Assaf Weiner; Orit Matcovitch-Natan; Raz Dvir-Szternfeld; Tyler K Ulland; Eyal David; Kuti Baruch; David Lara-Astaiso; Beata Toth; Shalev Itzkovitz; Marco Colonna; Michal Schwartz; Ido Amit
Journal:  Cell       Date:  2017-06-08       Impact factor: 41.582

5.  New tools for studying microglia in the mouse and human CNS.

Authors:  Mariko L Bennett; F Chris Bennett; Shane A Liddelow; Bahareh Ajami; Jennifer L Zamanian; Nathaniel B Fernhoff; Sara B Mulinyawe; Christopher J Bohlen; Aykezar Adil; Andrew Tucker; Irving L Weissman; Edward F Chang; Gordon Li; Gerald A Grant; Melanie G Hayden Gephart; Ben A Barres
Journal:  Proc Natl Acad Sci U S A       Date:  2016-02-16       Impact factor: 11.205

6.  Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription.

Authors:  Minna U Kaikkonen; Nathanael J Spann; Sven Heinz; Casey E Romanoski; Karmel A Allison; Joshua D Stender; Hyun B Chun; David F Tough; Rab K Prinjha; Christopher Benner; Christopher K Glass
Journal:  Mol Cell       Date:  2013-08-08       Impact factor: 17.970

7.  A Comprehensive Profile of ChIP-Seq-Based PU.1/Spi1 Target Genes in Microglia.

Authors:  Jun-Ichi Satoh; Naohiro Asahina; Shouta Kitano; Yoshihiro Kino
Journal:  Gene Regul Syst Bio       Date:  2014-12-08

8.  Differentiation of human and murine induced pluripotent stem cells to microglia-like cells.

Authors:  Hetal Pandya; Michael J Shen; David M Ichikawa; Andrea B Sedlock; Yong Choi; Kory R Johnson; Gloria Kim; Mason A Brown; Abdel G Elkahloun; Dragan Maric; Colin L Sweeney; Selamawit Gossa; Harry L Malech; Dorian B McGavern; John K Park
Journal:  Nat Neurosci       Date:  2017-03-02       Impact factor: 24.884

9.  Factors regulating microglia activation.

Authors:  Katrin Kierdorf; Marco Prinz
Journal:  Front Cell Neurosci       Date:  2013-04-23       Impact factor: 5.505

10.  M-CSF increases proliferation and phagocytosis while modulating receptor and transcription factor expression in adult human microglia.

Authors:  Amy M Smith; Hannah M Gibbons; Robyn L Oldfield; Peter M Bergin; Edward W Mee; Maurice A Curtis; Richard L M Faull; Mike Dragunow
Journal:  J Neuroinflammation       Date:  2013-07-17       Impact factor: 8.322
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  18 in total

Review 1.  Schistosome and intestinal helminth modulation of macrophage immunometabolism.

Authors:  Diana Cortes-Selva; Keke Fairfax
Journal:  Immunology       Date:  2020-07-27       Impact factor: 7.397

2.  Atg7 deficiency in microglia drives an altered transcriptomic profile associated with an impaired neuroinflammatory response.

Authors:  Lara Friess; Mathilde Cheray; Lily Keane; Kathleen Grabert; Bertrand Joseph
Journal:  Mol Brain       Date:  2021-06-03       Impact factor: 4.041

Review 3.  Alterations in Chromatin Structure and Function in the Microglia.

Authors:  Yuki Fujita; Toshihide Yamashita
Journal:  Front Cell Dev Biol       Date:  2021-01-21

Review 4.  Microglia-Mediated Neurodegeneration in Perinatal Brain Injuries.

Authors:  Bobbi Fleiss; Juliette Van Steenwinckel; Cindy Bokobza; Isabelle K Shearer; Emily Ross-Munro; Pierre Gressens
Journal:  Biomolecules       Date:  2021-01-13

Review 5.  Epigenetic Modulation of Microglia Function and Phenotypes in Neurodegenerative Diseases.

Authors:  Li Wang; Chao-Chao Yu; Xin-Yuan Liu; Xiao-Ni Deng; Qing Tian; Yan-Jun Du
Journal:  Neural Plast       Date:  2021-05-29       Impact factor: 3.599

6.  PU.1 inhibition attenuates atrial fibrosis and atrial fibrillation vulnerability induced by angiotensin-II by reducing TGF-β1/Smads pathway activation.

Authors:  Juan Hu; Jing-Jing Zhang; Li Li; Shan-Ling Wang; Hai-Tao Yang; Xian-Wei Fan; Lei-Ming Zhang; Guang-Ling Hu; Hai-Xia Fu; Wei-Feng Song; Li-Jie Yan; Jing-Jing Liu; Jin-Tao Wu; Bin Kong
Journal:  J Cell Mol Med       Date:  2021-06-15       Impact factor: 5.310

7.  Inhibition of colony stimulating factor 1 receptor corrects maternal inflammation-induced microglial and synaptic dysfunction and behavioral abnormalities.

Authors:  Seiko Ikezu; Hana Yeh; Jean-Christophe Delpech; Maya E Woodbury; Alicia A Van Enoo; Zhi Ruan; Sudhir Sivakumaran; Yang You; Carl Holland; Teresa Guillamon-Vivancos; Asuka Yoshii-Kitahara; Mina B Botros; Charlotte Madore; Pin-Hao Chao; Ankita Desani; Solaiappan Manimaran; Srinidhi Venkatesan Kalavai; W Evan Johnson; Oleg Butovsky; Maria Medalla; Jennifer I Luebke; Tsuneya Ikezu
Journal:  Mol Psychiatry       Date:  2020-02-18       Impact factor: 13.437

8.  Identification and characterization of microglia/macrophages in the granuloma microenvironment of encephalic schistosomiasis japonicum.

Authors:  Zhoubin Tan; Zhuowei Lei; Zhuo Zhang; Huaqiu Zhang; Kai Shu; Feng Hu; Ting Lei
Journal:  BMC Infect Dis       Date:  2019-12-30       Impact factor: 3.090

9.  Inducible cell-specific mouse models for paired epigenetic and transcriptomic studies of microglia and astroglia.

Authors:  Ana J Chucair-Elliott; Sarah R Ocañas; David R Stanford; Victor A Ansere; Kyla B Buettner; Hunter Porter; Nicole L Eliason; Justin J Reid; Amanda L Sharpe; Michael B Stout; Michael J Beckstead; Benjamin F Miller; Arlan Richardson; Willard M Freeman
Journal:  Commun Biol       Date:  2020-11-19

Review 10.  Microglia in neurodegenerative diseases.

Authors:  Yu Xu; Ming-Zhu Jin; Ze-Yong Yang; Wei-Lin Jin
Journal:  Neural Regen Res       Date:  2021-02       Impact factor: 5.135
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