Shao-Wei Xue1, Qingbao Yu2, Yonghu Guo1, Donghui Song1, Ze Wang3. 1. Center for Cognition and Brain Disorders, Institutes of Psychological Sciences and the Affiliated Hospital, Hangzhou Normal University, Hangzhou 311121, China; Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou 311121, China. 2. The Mind Research Network, Albuquerque, NM 87106, USA. 3. Department of Radiology, Lewis Katz School of Medicine, Temple University, USA. Electronic address: zewangnew@temple.edu.
Abstract
BACKGROUND: The human brain presents ongoing temporal fluctuations whose dynamic range indicates the capacity of information processing and can be approximately quantified with entropy. Using functional magnetic resonance imaging (fMRI), recent studies have shown a stable distribution pattern of temporal brain entropy (tBEN) in healthy subjects, which may be affected by neuropsychiatric diseases such as schizophrenia. Assessing tBEN may reciprocally provide a new tool to characterize those disorders. METHODS: The current study aimed to identify tBEN changes in schizophrenia patients using publicly available data from the Centers of Biomedical Research Excellence (COBRE) project. Forty-three schizophrenia patients and 59 sex- and age-matched healthy control subjects were included, and tBEN was calculated from their resting-state fMRI scans. RESULTS: Compared with healthy controls, patients showed decreased tBEN in the right middle prefrontal cortex, bilateral thalamus, right hippocampus and bilateral caudate and increased tBEN in the left lingual gyrus, left precuneus, right fusiform face area and right superior occipital gyrus. In schizophrenia patients, tBEN in the left cuneus and middle occipital gyrus was negatively correlated with the positive and negative syndrome scores (PANSS). Age of onset was inversely correlated with tBEN in the right fusiform gyrus and left insula. CONCLUSION: Our findings demonstrate a detrimental tBEN reduction in schizophrenia that is related to clinical characteristics. The tBEN increase in a few regions might be a result of tBEN redistribution across the whole brain in schizophrenia.
BACKGROUND: The human brain presents ongoing temporal fluctuations whose dynamic range indicates the capacity of information processing and can be approximately quantified with entropy. Using functional magnetic resonance imaging (fMRI), recent studies have shown a stable distribution pattern of temporal brain entropy (tBEN) in healthy subjects, which may be affected by neuropsychiatric diseases such as schizophrenia. Assessing tBEN may reciprocally provide a new tool to characterize those disorders. METHODS: The current study aimed to identify tBEN changes in schizophreniapatients using publicly available data from the Centers of Biomedical Research Excellence (COBRE) project. Forty-three schizophreniapatients and 59 sex- and age-matched healthy control subjects were included, and tBEN was calculated from their resting-state fMRI scans. RESULTS: Compared with healthy controls, patients showed decreased tBEN in the right middle prefrontal cortex, bilateral thalamus, right hippocampus and bilateral caudate and increased tBEN in the left lingual gyrus, left precuneus, right fusiform face area and right superior occipital gyrus. In schizophreniapatients, tBEN in the left cuneus and middle occipital gyrus was negatively correlated with the positive and negative syndrome scores (PANSS). Age of onset was inversely correlated with tBEN in the right fusiform gyrus and left insula. CONCLUSION: Our findings demonstrate a detrimental tBEN reduction in schizophrenia that is related to clinical characteristics. The tBEN increase in a few regions might be a result of tBEN redistribution across the whole brain in schizophrenia.
Authors: Landrew Sevel; Bethany Stennett; Victor Schneider; Nicholas Bush; Sara Jo Nixon; Michael Robinson; Jeff Boissoneault Journal: Alcohol Clin Exp Res Date: 2020-06-18 Impact factor: 3.455