Berna Aksoy1,2, Özlem Ekiz3, Emine Unal4, Goknur Ozaydin Yavuz5, Müzeyyen Gonul6, Seray Kulcu Cakmak7, Mualla Polat8, Özlem Bilgic9, Leyla Baykal Selcuk10, Idil Unal11, Ayse S Karadag12, Arzu Kilic13, Ilknur Balta3, Ömer Kutlu3, Tuğba K Uzuncakmak12, Kamer Gunduz14. 1. Faculty of Medicine, Department of Dermatology, Bahcesehir University, Istanbul, Turkey. 2. Clinic of Dermatology, VM Medicalpark Hospital, Kocaeli, Turkey. 3. Dermatology Clinic, Ankara Training and Research Hospital, Ankara, Turkey. 4. Dermatology Clinic, Yenimahalle Training and Research Hospital, Ankara, Turkey. 5. Faculty of Medicine, Department of Dermatology, Yuzuncu Yil University, Van, Turkey. 6. Dermatology Clinic, Dıskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey. 7. Dermatology Clinic, Numune Training and Research Hospital, Ankara, Turkey. 8. Faculty of Medicine, Department of Dermatology, Abant Izzet Baysal University, Bolu, Turkey. 9. Dermatology Clinic, Private Erdem Hospital, Istanbul, Turkey. 10. Faculty of Medicine, Department of Dermatology, Karadeniz Technical University, Trabzon, Turkey. 11. Faculty of Medicine, Department of Dermatology, Ege University, Izmir, Turkey. 12. Faculty of Medicine, Goztepe Training and Research Hospital, Department of Dermatology, Istanbul Medeniyet University, Istanbul, Turkey. 13. Faculty of Medicine, Department of Dermatology, Balikesir University, Balikesir, Turkey. 14. Faculty of Medicine, Department of Dermatology, Celal Bayar University, Manisa, Turkey.
Abstract
BACKGROUND: Once considered a disorder limited to the skin, rosacea is now known to be associated with systemic disorders. The aim of this study was to determine what systemic comorbidities accompany rosacea and to determine the relationship between the type, severity, and duration of rosacea, and the presence of and type of systemic comorbidities. METHODS: This retrospective multicenter study was conducted by the Turkish Society of Dermatology Acne Study Group. Thirteen dermatology clinics throughout Turkey participated in the study. A structured physician-administered questionnaire was used to collect patient demographics, clinical findings, and lifestyle data. The principal rosacea subtype, physician global assessment of severity, and duration of rosacea were recorded. Physicians recorded each participant's medical history, including current and past comorbidities, duration of any such comorbidity, and the use of medications to treat any comorbidities. RESULTS: The study included 1,195 rosacea patients and 621 controls without rosacea aged 18-85 years. As compared to the controls, more of the rosacea patients had respiratory tract, gastrointestinal system, and metabolic and hepatobiliary system disorders in a rosacea's severity- and duration-dependent manner. CONCLUSION: Clinicians must be aware of the potential for systemic comorbidities in rosacea patients, which becomes more likely as disease duration and severity increase.
BACKGROUND: Once considered a disorder limited to the skin, rosacea is now known to be associated with systemic disorders. The aim of this study was to determine what systemic comorbidities accompany rosacea and to determine the relationship between the type, severity, and duration of rosacea, and the presence of and type of systemic comorbidities. METHODS: This retrospective multicenter study was conducted by the Turkish Society of Dermatology Acne Study Group. Thirteen dermatology clinics throughout Turkey participated in the study. A structured physician-administered questionnaire was used to collect patient demographics, clinical findings, and lifestyle data. The principal rosacea subtype, physician global assessment of severity, and duration of rosacea were recorded. Physicians recorded each participant's medical history, including current and past comorbidities, duration of any such comorbidity, and the use of medications to treat any comorbidities. RESULTS: The study included 1,195 rosaceapatients and 621 controls without rosacea aged 18-85 years. As compared to the controls, more of the rosaceapatients had respiratory tract, gastrointestinal system, and metabolic and hepatobiliary system disorders in a rosacea's severity- and duration-dependent manner. CONCLUSION: Clinicians must be aware of the potential for systemic comorbidities in rosaceapatients, which becomes more likely as disease duration and severity increase.