Hyung-Kook Kim1, You Jin Lee2, Young-Kyun Lee1, Hongji Kim1, Kyung-Hoi Koo1. 1. Department of Orthopaedic Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea. 2. Department of Internal Medicine, Center for Thyroid Cancer, National Cancer Center, Goyang, Korea.
Abstract
BACKGROUND: Although studies and interest in sarcopenia have increased, it is still a matter of debate which muscle mass index better represents the aging process. We compared 3 indices for muscle mass (appendicular skeletal muscle mass [ASM]/weight, ASM/height2, and the body mass index [BMI]-adjusted muscle mass index [ASM/BMI]) to determine which better reflected the aging process in terms of the decline in bone mineral density (BMD), visual acuity (VA), hearing power, renal function, pulmonary function, and handgrip strength. METHODS: We performed a retrospective cross-sectional study using the Korea National Health and Nutrition Examination Survey in the Korean population. Between 2008 and 2011, a total of 14,415 men and 17,971 women aged 10 years or older participated in the study. We plotted the changes in the 3 indices of muscle mass and compared these with changes in BMD, VA, hearing power, renal function, pulmonary function, and handgrip strength according to each age group. RESULTS: The ASM/BMI showed similar changes in terms of surrogate markers of the aging process, while the ASM/weight and ASM/height2 showed no correlation. CONCLUSIONS: Among muscle indices for sarcopenia, only the ASM/BMI represented the aging process.
BACKGROUND: Although studies and interest in sarcopenia have increased, it is still a matter of debate which muscle mass index better represents the aging process. We compared 3 indices for muscle mass (appendicular skeletal muscle mass [ASM]/weight, ASM/height2, and the body mass index [BMI]-adjusted muscle mass index [ASM/BMI]) to determine which better reflected the aging process in terms of the decline in bone mineral density (BMD), visual acuity (VA), hearing power, renal function, pulmonary function, and handgrip strength. METHODS: We performed a retrospective cross-sectional study using the Korea National Health and Nutrition Examination Survey in the Korean population. Between 2008 and 2011, a total of 14,415 men and 17,971 women aged 10 years or older participated in the study. We plotted the changes in the 3 indices of muscle mass and compared these with changes in BMD, VA, hearing power, renal function, pulmonary function, and handgrip strength according to each age group. RESULTS: The ASM/BMI showed similar changes in terms of surrogate markers of the aging process, while the ASM/weight and ASM/height2 showed no correlation. CONCLUSIONS: Among muscle indices for sarcopenia, only the ASM/BMI represented the aging process.
Authors: John E Morley; Angela Marie Abbatecola; Josep M Argiles; Vickie Baracos; Juergen Bauer; Shalender Bhasin; Tommy Cederholm; Andrew J Stewart Coats; Steven R Cummings; William J Evans; Kenneth Fearon; Luigi Ferrucci; Roger A Fielding; Jack M Guralnik; Tamara B Harris; Akio Inui; Kamyar Kalantar-Zadeh; Bridget-Anne Kirwan; Giovanni Mantovani; Maurizio Muscaritoli; Anne B Newman; Filippo Rossi-Fanelli; Giuseppe M C Rosano; Ronenn Roubenoff; Morris Schambelan; Gerald H Sokol; Thomas W Storer; Bruno Vellas; Stephan von Haehling; Shing-Shing Yeh; Stefan D Anker Journal: J Am Med Dir Assoc Date: 2011-07 Impact factor: 4.669
Authors: Takashi Abe; Robert S Thiebaud; Jeremy P Loenneke; Michael G Bemben; Mark Loftin; Tetsuo Fukunaga Journal: Metab Syndr Relat Disord Date: 2012-07-20 Impact factor: 1.894
Authors: Francesco Landi; Rosa Liperoti; Domenico Fusco; Simona Mastropaolo; Davide Quattrociocchi; Anna Proia; Matteo Tosato; Roberto Bernabei; Graziano Onder Journal: J Am Med Dir Assoc Date: 2012-02 Impact factor: 4.669
Authors: Roger A Fielding; Bruno Vellas; William J Evans; Shalender Bhasin; John E Morley; Anne B Newman; Gabor Abellan van Kan; Sandrine Andrieu; Juergen Bauer; Denis Breuille; Tommy Cederholm; Julie Chandler; Capucine De Meynard; Lorenzo Donini; Tamara Harris; Aimo Kannt; Florence Keime Guibert; Graziano Onder; Dimitris Papanicolaou; Yves Rolland; Daniel Rooks; Cornel Sieber; Elisabeth Souhami; Sjors Verlaan; Mauro Zamboni Journal: J Am Med Dir Assoc Date: 2011-03-04 Impact factor: 4.669
Authors: Anne B Newman; Varant Kupelian; Marjolein Visser; Eleanor Simonsick; Bret Goodpaster; Michael Nevitt; Stephen B Kritchevsky; Frances A Tylavsky; Susan M Rubin; Tamara B Harris Journal: J Am Geriatr Soc Date: 2003-11 Impact factor: 5.562
Authors: Alfonso J Cruz-Jentoft; Jean Pierre Baeyens; Jürgen M Bauer; Yves Boirie; Tommy Cederholm; Francesco Landi; Finbarr C Martin; Jean-Pierre Michel; Yves Rolland; Stéphane M Schneider; Eva Topinková; Maurits Vandewoude; Mauro Zamboni Journal: Age Ageing Date: 2010-04-13 Impact factor: 10.668
Authors: Marcos Estrada; Alison Kleppinger; James O Judge; Stephen J Walsh; George A Kuchel Journal: J Am Geriatr Soc Date: 2007-11 Impact factor: 5.562